Document Type
Article
Publication Date
2025
Publication Title
Physical Biology
Volume
22
Issue
2
Pages
026001 (1-12)
DOI
10.1088/1478-3975/adaa47
Abstract
The electric potential across the inner mitochondrial membrane must be maintained within certain bounds for the proper functioning of the cell. A feedback control mechanism for the homeostasis of this membrane potential is proposed whereby an increase in the electric field decreases the rate-limiting steps of the electron transport chain (ETC). An increase in trans-membrane electric field limits the rate of proton pumping to the inter-membrane gap by slowing the ETC reactions and by intrinsically induced electroporation that depolarizes the inner membrane. The proposed feedback mechanism is akin to a Le Chatelier's-type principle of trans-membrane potential feedback control.
Rights
© 2025 The Authors
Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Any further distribution of this work must maintain attribution to the authors and the title of the work, journal citation and DOI.
Data Availability
Article States: "All data that support the findings of this study are included within the article (and any supplementary files)."
Original Publication Citation
Fahimi, P., Castanedo, L. A. M., Vernier, P. T., & Matta, C. F. (2025). Electrical homeostasis of the inner mitochondrial membrane potential. Physical Biology, 22(2), 1-12, Article 026001. https://doi.org/10.1088/1478-3975/adaa47
Repository Citation
Fahimi, Peyman; Castanedo, Lázaro A. M.; Vernier, P. Thomas; and Matta, Cherif F., "Electrical Homeostasis of the Inner Mitochondrial Membrane Potential" (2025). Bioelectrics Publications. 376.
https://digitalcommons.odu.edu/bioelectrics_pubs/376
ORCID
0000-0003-2335-1500 (Vernier)
Included in
Biochemistry, Biophysics, and Structural Biology Commons, Biology Commons, Endocrinology, Diabetes, and Metabolism Commons, Membrane Science Commons
