Document Type
Article
Publication Date
2025
Publication Title
Critical Reviews in Oncology Hematology
Volume
215
Pages
104903
DOI
10.1016/j.critrevonc.2025.104903
Abstract
Surgery has traditionally been a cornerstone in cancer treatment, yet its feasibility can be limited by factors such as tumor location and patient health conditions. When surgery is not viable, thermal and pulsed electric field (PEF)-based ablation technologies offer valuable alternatives. Emerging evidence suggests that these approaches not only target tumors effectively but also stimulate antitumor immune responses. In this review, we begin by examining the distinctive features of hyperthermic treatments (radiofrequency and microwave ablation), cryoablation, and PEF-technologies. Subsequently, we discuss the mechanisms of cell death, stress responses, and release of danger signals triggered by these diverse ablation technologies. Finally, we explore their potential synergies with clinically approved immunotherapies.
Rights
© 2025 The Authors.
This is an open access article under the Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Original Publication Citation
Rossi, A., & Muratori, C. (2025). Physical ablative methods and cancer cell death: Implications for immunity and therapies. Critical Reviews in Oncology Hematology, 215, 1-12, Article 104903. https://doi.org/10.1016/j.critrevonc.2025.104903
Repository Citation
Rossi, Alessandra and Muratori, Claudia, "Physical Ablative Methods and Cancer Cell Death: Implications for Immunity and Therapies" (2025). Bioelectrics Publications. 380.
https://digitalcommons.odu.edu/bioelectrics_pubs/380
ORCID
0000-0001-9042-3549 (Rossi), 0000-0002-3359-164X (Muratori)