Document Type
Article
Publication Date
1999
Publication Title
Genes Chromosomes & Cancer
Volume
25
Issue
2
Pages
191-193
DOI
10.1002/(SICI)1098-2264(199906)25:2<191::AID-GCC16>3.0.CO;2-8
Abstract
The t(8;21) between the AML1 and ETO genes is a commonly seen genetic alteration in acute myeloid leukemia. Recently, we reported that the fusion partner ETO binds to the human nuclear receptor co-repressor (NCOR), a member of the NCOR/SIN3/histone deacetylase complex. This complex mediates transcriptional repression as a result of chromatin remodeling. Here, we used a combination of fluorescence in situ hybridization and hybrid panels to localize the human NCOR gene (NCOR) to chromosome band 17p11.2. The position of human NCOR on 17p11 raises the possibility of deranged transcriptional regulation in malignant disorders associated with deletions of 17p.
Rights
Copyright © 1999-2026 John Wiley & Sons, Inc or related companies.
This article is a US Government work and, as such, is in the public domain in the United States of America. Foreign copyright applies.
Original Publication Citation
Stacey, M. W., Wang, J., Byrd, R. L., Liu, J. M., & Kearns, W. G. (1999). Nuclear receptor co-repressor gene localizes to 17p11.2, a frequently deleted band in malignant disorders. Genes Chromosomes Cancer, 25(2), 191-193. https://doi.org/10.1002/(SICI)1098-2264(199906)25:2<191::AID-GCC16>3.0.CO;2-8
Repository Citation
Stacey, Michael W.; Wang, Jianxiang; Byrd, Rebecca L.; Liu, Johnson M.; and Kearns, William G., "Nuclear Receptor Co-Repressor Gene Localizes to 17p11.2, a Frequently Deleted Band in Malignant Disorders" (1999). Bioelectrics Publications. 384.
https://digitalcommons.odu.edu/bioelectrics_pubs/384
ORCID
0000-0002-3807-6233 (Stacey)
Included in
Amino Acids, Peptides, and Proteins Commons, Genetics and Genomics Commons, Medical Genetics Commons