Document Type
Article
Publication Date
2026
Publication Title
Vascular Pharmacology
Volume
163
Pages
107615
DOI
10.1016/j.vph.2026.107615
Abstract
The human lung normally accommodates exercise-induced cardiac output increases mainly via recruitment of non-concomitantly perfused pulmonary capillaries. Recruitment is detectable by measuring the first-pass transpulmonary metabolism of ³H-benzoyl-Phe-Ala-Pro, providing an estimate of functional capillary surface area (FCSA). Pulmonary arterial hypertension (PAH) results from luminal narrowing of small precapillary arterioles, reducing downstream perfused FCSA. We hypothesized that exercising PAH patients would not be able to recruit FCSA normally. We studied two patients with severe PAH. Despite exercising to maximal dyspnea, neither could recruit FCSA. These limited data are the first direct measurements of FCSA in exercising PAH patients.
Rights
© 2026 The Authors
This is an open access article under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) License.
Data Availability
Article states: "The data that have been used are confidential."
Original Publication Citation
Langleben, D., Orfanos, S. E., Fox, B. D., Giovinazzo, M., Kaddis, M., & Catravas, J. D. (2026). Decreased exercise-induced pulmonary capillary recruitment in pulmonary arterial hypertension. Vascular Pharmacology, 163, Article 107615. https://doi.org/10.1016/j.vph.2026.107615
Repository Citation
Langleben, David; Orfanos, Stylianos E.; Fox, Benjamin D.; Giovinazzo, Michele; Kaddis, Magali; and Catravas, John D., "Decreased Exercise-Induced Pulmonary Capillary Recruitment in Pulmonary Arterial Hypertension" (2026). Bioelectrics Publications. 387.
https://digitalcommons.odu.edu/bioelectrics_pubs/387
ORCID
0000-0002-5098-295X (Catravas)
Included in
Exercise Science Commons, Nutritional and Metabolic Diseases Commons, Respiratory System Commons