Document Type

Article

Publication Date

2025

DOI

10.1002/open.202500304

Publication Title

ChemistryOpen

Volume

14

Issue

11

Pages

e202500304 (1-24 pp.)

Abstract

Electrochemical glucose sensing technologies have undergone significant evolution, with continual advancements aimed at improving sensitivity, selectivity, and user convenience. This review systematically explores the development of emerging nonenzymatic glucose sensor designs. Nonenzymatic sensors are critically evaluated for their ability to overcome enzymatic limitations, leveraging novel materials and catalytic mechanisms. Additionally, the emergence of smartphone-integrated glucose monitoring systems is highlighted as the fifth generation, representing a paradigm shift toward personalized, real-time healthcare management. Emphasis is placed on the strategies employed to reduce the working electrode potential and enhance analytical performance. Key analytical metrics and real-sample applicability are evaluated, and persistent challenges including reliability, biocompatibility, and calibration-free operation are identified. Further, this review provides a critical perspective on the trajectory of electrochemical nonenzymatic glucose sensor technologies and outlines future directions toward the development of next-generation platforms for continuous and noninvasive glucose monitoring.

Comments

© 2025 The Authors. ChemistryOpen published by Wiley-VCH GmbH.

This is an open access article under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Original Publication Citation

Aviha, R., & Slaughter, G. (2025). Electrochemical and nanomaterial-based strategies for nonenzymatic glucose detection: A review. ChemistryOpen,14(11), Article e202500304. https://doi.org/10.1002/open.202500304

ORCID

0000-0002-4307-091X (Slaughter)

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