Document Type

Article

Publication Date

2026

DOI

10.1039/d6ra04298h

Publication Title

RSC Advances

Volume

Advance online publication

Pages

15 pp.

Abstract

Continuous glucose monitoring is critical for effective diabetes management; however, conventional benchtop potentiostats are bulky, costly, and unsuitable for decentralized point-of-care (PoC) applications. To address these limitations, this work presents a miniaturized, low-cost electrochemical sensing platform integrating a non-enzymatic glucose sensor with a portable potentiostat. The sensing electrode is based on laser-induced graphene modified with zinc oxide and platinum nanostructures via electrodeposition to enable sensitive glucose detection under physiological conditions. A custom-designed portable potentiostat was developed to control electrode potentials and perform electrochemical measurements, and its performance was experimentally validated against a commercial Metrohm system. Glucose detection was evaluated using cyclic voltammetry (CV) and chronoamperometry (CA). The sensor exhibited a sensitivity of 49.0 µA mM−1 cm−2 over a dynamic range of 1–16 mM using CV, and 7.375 µA mM−1 cm−2 over 0.5–26 mM using CA at +0.40 V, with a detection limit of 251.02 µM. The portable potentiostat demonstrated comparable performance to the commercial system, with a deviation of 9.23%. These results demonstrate the feasibility of integrating non-enzymatic sensing with portable electronics to achieve reliable and cost-effective glucose detection. The developed platform provides a scalable pathway toward accessible, decentralized PoC diagnostics and wearable biosensing applications.

Comments

© 2026 The Authors.

This article is licensed under a Creative Commons Attribution-Non Commercial 4.0 International (CC BY-NC 4.0) License. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

Data availability statement: Article states: "The data supporting the findings of this work are available within the article."

Original Publication Citation

Aviha, R., & Slaughter, G. (2026). A portable potentiostat integrated with a Pt/ZnO/LIG electrode for non-enzymatic glucose detection. RSC Advances. Advance online publication. https://doi.org/10.1039/d6ra04298h

ORCID

0000-0002-4307-091X (Slaughter)

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