Document Type

Article

Publication Date

2026

DOI

10.1021/acsbiomaterials.6c00880

Publication Title

ACS Biomaterials Science & Engineering

Volume

12

Issue

8

Pages

4067-4093

Abstract

Antimicrobial resistance (AMR) is a major global health challenge driven by mechanisms such as biofilm formation, efflux pumps, and genetic mutations. Nanoparticulate and fibrous materials have emerged as promising strategies to overcome these limitations through multimodal antimicrobial action and controlled drug delivery. This review highlights recent advances in electrospun nanofibrous systems, including natural and synthetic polymer-based scaffolds, stimuli-responsive nanofibers, and functionalized patches. Nanoparticle-loaded nanofiber systems demonstrate enhanced performance, including bacterial eradication, sustained drug release, and significant biofilm disruption. Multifunctional systems combining antimicrobial, antioxidant, and immunomodulatory properties further show synergism. Emerging innovations, such as piezoelectric and smart sensing systems, enable self-powered antimicrobial activity and real-time infection monitoring with high detection accuracy. The nanostructured systems reported in this review provide a versatile and effective strategy for combating AMR.

Comments

© 2026 The Authors.

This publication is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.

Original Publication Citation

Ujjwal, R. R., Sutar, A. D., Shukla, R., & Slaughter, G. (2026). Nanofibrous materials and nanoparticles for combating antimicrobial resistance: Synthesis, integration, and translational perspectives. ACS Biomaterials Science & Engineering, 12(8), 4067-4093. https://doi.org/10.1021/acsbiomaterials.6c00880

ORCID

0000-0002-4307-091X (Slaughter)

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