Document Type

Article

Publication Date

2-2014

DOI

10.1016/j.jneuroim.2013.12.002

Publication Title

Journal of Neuroimmunology

Volume

267

Issue

1-2

Pages

50-60

Abstract

We report herein that neuroinvasion by vesicular stomatitis virus (VSV) activates microglia and induces a peripheral dendritic cell (DC)-dependent inflammatory response in the central nervous system (CNS). VSV neuroinvasion rapidly induces multiple brain chemokine and proinflammatory cytokine mRNAs that display bimodal kinetics. Peripheral DC ablation or T cell depletion suppresses the second wave of this response demonstrating that infiltrating T cells are primarily responsible for the bimodal characteristics of this response. The robust infiltrate associated with VSV encephalitis likely depends on sustained production of brain CCL19 and CCR7 expression on infiltrating inflammatory cells. © 2013 Elsevier B.V. All rights reserved.

Comments

This is the author's unedited manuscript. The article was published in final edited form as:

Steel, C. D., Breving, K., Tavakoli, S., Kim, W. K., Sanford, L. D., & Ciavarra, R. P. (2014). Role of peripheral immune response in microglia activation and regulation of brain chemokine and proinflammatory cytokine responses induced during VSV encephalitis. Journal of Neuroimmunology, 267(1-2), 50-60. doi:10.1016/j.jneuroim.2013.12.002

Original Publication Citation

Steel, C. D., Breving, K., Tavakoli, S., Kim, W. K., Sanford, L. D., & Ciavarra, R. P. (2014). Role of peripheral immune response in microglia activation and regulation of brain chemokine and proinflammatory cytokine responses induced during VSV encephalitis. Journal of Neuroimmunology, 267(1-2), 50-60. doi:10.1016/j.jneuroim.2013.12.002

ORCID

0000-0003-3551-8400 (Steel)

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