Document Type
Article
Publication Date
2019
DOI
10.1111/bjd.17886
Publication Title
British Journal of Dermatology
Pages
1-23
Abstract
BACKGROUND: Anti-C1q autoantibodies (autoAbs) are associated with systemic lupus erythematosus (SLE) but their presence in other rheumatic diseases has not been adequately investigated.
OBJECTIVE: We aim to assessanti-C1q autoAbs and circulating immune complexes (CICs) in systemic sclerosis (SSc).
METHODS: One hundred twenty four patients with SSc (106 females; median age 59.4 years, range 25-81.4; 75(60.5%) with limited cutaneous SSc[lcSSc], and 49(39.5%) with diffuse cutaneous SSc[dcSSc]), were studied. Twenty-five patients with Sjögren's syndrome (SjS), 29 with rheumatoid arthritis (RA), and 38 patients with systemic lupus erythematosus (SLE) and 53 healthy controls (NC) were also included. ELISAs with high and low salt buffers the former allowing IgGFc binding to C1q, the latter not allowing IgGFc binding and anti-C1q Ab binding to C1q were used to measure anti-C1q Abs and CICs.
RESULTS: Anti-C1q Abs were present in20/124 (16.1%) SSc patients [5 had high levels (>80 RU/mL) and 10 patients (50%) had moderate levels (40-80 RU/mL)] compared to 1/25 (4%) SjS, 1/29 (3.4%) RA patients (p
CONCLUSIONS: Anti-C1q autoAbs were frequently detected in patients with SSc and their high levels predict the co-occurrence of pulmonary fibrosis or pulmonary arterial hypertension.
Rights
This is the peer reviewed version of the following article:
Liaskos, C., Rentouli, S., Simopoulou, T., Gkoutzourelas, A., Norman, G. L., Brotis, A., . . . Sakkas, L. I. (2019). Anti-C1q autoantibodies are frequently detected in patients with systemic sclerosis associated with pulmonary fibrosis. British Journal of Dermatology. doi:10.1111/bjd.17886
which has been published in final form at https://doi.org/10.1111/bjd.17886
This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Original Publication Citation
Liaskos, C., Rentouli, S., Simopoulou, T., Gkoutzourelas, A., Norman, G. L., Brotis, A., . . . Sakkas, L. I. (2019). Anti-C1q autoantibodies are frequently detected in patients with systemic sclerosis associated with pulmonary fibrosis. British Journal of Dermatology. doi:10.1111/bjd.17886
Repository Citation
Liaskos, C.; Rentouli, S.; Simopoulou, T.; Gkoutzourelas, A.; Norman, G. L.; Brotis, A.; Alexiou, I.; Katsiari, C.; Bogdanos, D. P.; and Sakkas, L. I., "Anti-C1q Autoantibodies Are Frequently Detected in Patients With Systemic Sclerosis Associated With Pulmonary Fibrosis" (2019). Biological Sciences Faculty Publications. 375.
https://digitalcommons.odu.edu/biology_fac_pubs/375
ORCID
0000-0002-7670-3314 (Sakkas)