Date of Award

Fall 2017

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Electrical & Computer Engineering

Program/Concentration

Biomedical Engineering

Committee Director

Chunqi Jiang

Committee Member

Stephen Beebe

Committee Member

Siqi Guo

Committee Member

Michel Audette

Abstract

Pulsed Electric Fields (PEF) have promised improved treatment results in a variety of cancer types including melanoma, pancreatic and lung squamous cancer. Recent studies show that PEF-based cancer therapy may be improved further with the assistance of moderate heating of the target. Experiments were performed to design, calibrate and implement a feedback-looped infrared laser irradiation system that could maintain specified temperatures during the treatment. The exact treatment area, penetration depth and thermal distribution of a 980-nm laser fiber were quantified using several methods, including the knife-edge technique and a tissue optical property study. In vivo and in vitro experiments using this protocol show that there is a synergistic effect between PEF and the moderately elevated heating of a target, which resulted in an increased overall treatment area up to a factor of 5.6 in vitro as well as an increased the overall survival of the mice by 54% in the treatment of pancreatic cancer in mice.

DOI

10.25777/ehzr-kx19

ISBN

9780355778236

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