Date of Award

Fall 2017

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Biomedical Engineering

Committee Director

Chunqi Jiang

Committee Member

Stephen Beebe

Committee Member

Siqi Guo

Committee Member

Michel Audette

Abstract

Pulsed Electric Fields (PEF) have promised improved treatment results in a variety of cancer types including melanoma, pancreatic and lung squamous cancer. Recent studies show that PEF-based cancer therapy may be improved further with the assistance of moderate heating of the target. Experiments were performed to design, calibrate and implement a feedback-looped infrared laser irradiation system that could maintain specified temperatures during the treatment. The exact treatment area, penetration depth and thermal distribution of a 980-nm laser fiber were quantified using several methods, including the knife-edge technique and a tissue optical property study. In vivo and in vitro experiments using this protocol show that there is a synergistic effect between PEF and the moderately elevated heating of a target, which resulted in an increased overall treatment area up to a factor of 5.6 in vitro as well as an increased the overall survival of the mice by 54% in the treatment of pancreatic cancer in mice.

DOI

10.25777/ehzr-kx19

ISBN

9780355778236

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