Date of Award

Spring 2015

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Biomedical Engineering

Committee Director

Dean J. Krusienski

Committee Member

Michel A. Audette

Committee Member

Jiang Li

Committee Member

Christian W. Zemlin

Abstract

Hundreds of millions of people worldwide suffer from various neurological and psychiatric disorders. A better understanding of the underlying neurophysiology and mechanisms for these disorders can lead to improved diagnostic techniques and treatments. The objective of this dissertation is to create a novel characterization of multichannel EEG activity for selected neurological and psychiatric disorders based on available datasets. Specifically, this work provides spatial, spectral, and temporal characterizations of brain activity differences between patients/animal models and healthy controls, with focus on modern techniques that quantify cortical connectivity, which is widely believed to be abnormal in such disorders. Exploring the functional brain networks in these patients can provide a better understanding of the pathophysiology and brain network integrity of the respective disorders. This can allow for the assessment of neural mechanism deficits and possibly lead to developing a model for enhancement in the biology of neural interactions in these patients. This unique electrophysiological information may also contribute to the development of target drugs, novel treatments, and genetic studies. Moreover, the outcomes not only provide potential biomarkers for the diagnosis of respective disorders but also can serve as biofeedback for neurotherapy and also development of more sophisticated BCIs.

DOI

10.25777/xq0m-3t35

ISBN

9781321841329

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