Theses and dissertations published by graduate students in the Biomedical Sciences program, College of Sciences, Old Dominion University and the Joint Program between Old Dominion University and Eastern Virginia Medical School.

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Theses/Dissertations from 2015

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Dissertation: The Effects of Propofol, Sodium Pentobarbital, and Ketamine Hydrochloride on In Vitro Mouse Embryonic Development, Tyler C. Balak

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Dissertation: Investigation Into Protein Folding and Misfolding, Jason Charles Collins

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Dissertation: Exploring the Neuropeptides, Neuropeptide Receptors and Neurotransmitter Receptors in the Synganglia of Part-Fed Females of Ornithodoros turicata (Argasidae) and Ixodes scapularis (Ixodidae) with Insights Into Their Roles in Contrasting Biology, Noble I. Egekwu

Theses/Dissertations from 2014

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Dissertation: Mouse Oocyte Maturation and Embryo Development After Exposure to Vemurafenib (PLX4032), an Anti-Melanoma B-RAF V600E Inhibitor, Bo Liu

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Dissertation: Experimental and Computational Analysis of the Synucleins, Agatha Munyanyi

Theses/Dissertations from 2013

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Dissertation: New Tools for Real-Time Study of Embryonic Development, Lauren M. Browning

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Dissertation: Structural and Functional Study of Multidrug Membrane Transporters, Feng Ding

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Dissertation: Attachment Ability and Melanoma Inhibitory Activity mRNA Expression Level Changes in Murine B16-F10 Melanoma Cells Post Nanosecond Electric Pulses, Hongxia Jia

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Dissertation: New Types of Morpho-Physiological Changes in Cells Exposed to Nanosecond Pulsed Electric Field, Mikhail A. Rassokhin

Theses/Dissertations from 2012

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Dissertation: Nano- and Micro-Second Electrical Pulsing of B16-F10 Mouse Melanoma Cells: Plasma Membrane and Sub-Cellular Organelle Changes, Yiling Chen

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Dissertation: Treatment of Aortic Heart Valve Conduit with Glutamine and Heat Shock as a Means to Deter the Constituent Cellular Population From Becoming Apoptotic, Alyce Marie Linthurst Jones

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Dissertation: Design of In Vivo Assays for Study of Transport, Biocompatibility and Toxicity of Nanoparticles, Kerry Jean Lee

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Dissertation: The Dietary Isoprenoid Perillyl Alcohol Inhibits Telomerase Activity in Prostate Cancer Cells, Tabetha Sundin

Theses/Dissertations from 2011

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Dissertation: Age-Related Hamster Mitochondrial Changes and Oocyte Changes Following Autologous Platelet Mitochondrial Microinjection, Fang Li

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Dissertation: Nanosecond Pulsed Electric Field Induction of Programmed Cell Death Is Cell Type Dependent: An in vitro Study, Wei Ren

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Dissertation: Altering Nitric Oxide Bioavailability and Lipid Profiles in Endothelial Cells By Polycyclic Aromatic Hydrocarbons in Particulate Matter, Liang Yu

Theses/Dissertations from 2010

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Dissertation: Group II Metabolic Glutamate Receptors in the Basal Amygdala Regulate Sleep and Fear-Induced Alterations in Sleep, Enheng Dong

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Dissertation: Organization of Human Sperm Chromosomes During Pronuclei Formation, Estella Jones

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Dissertation: Cellular Immunity in Mouse Models of Viral Encephalitis, Christina Dawn Steel

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Dissertation: The Effects of Cocaine and Ecstasy on Cardiac Myocytes and the Intact Myocardium, David A. Tiangco

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Dissertation: Characterization of Metastasis-Associated Cell Surface Glycoproteins in Prostate Cancer, Lifang Yang

Theses/Dissertations from 2009

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Dissertation: Mechanisms of Regulation of Proximal Tubule Sodium Transporters in Obesity-Induced Hypertension, Marta A. Ambrozewicz

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Dissertation: Comparison of Immune Correlates, Age Related Changes and Proteomic Profiling of Healthy Individuals Receiving Influenza Vaccines, Gaurav Basu

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Dissertation: Study of the DNA Damage Complexes Within the HTLV-1 Tax Oncoprotein Interactome, Sidi Mehdi Belgnaoui

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Dissertation: Interdependent Regulation of Cytomegalovirus Proteins in Complex, Lisa L. Bolin

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Dissertation: Role of the Human Cytomegalovirus IE2 Protein on Transcriptional Regulation of Viral Promoters, Siabhon Michelle Harris

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Dissertation: Phosphorylation of the Estrogen Receptor Alpha (ERα) at Serine 118 by Phospho-p44/42 MAPK and Regulation by Estrogen and Progesterone in Human Uterine Leiomyoma Tissue and Cells, Tonia Lakisha Hermon

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Dissertation: Effects of HZE Irradiation on Chemical Neurotransmission in Rodent Hippocampus, Mayumi Machida

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Dissertation: Molecular Dynamics Study of Single Stranded Peptide Nucleic Acids, Anna K. Manukyan

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Dissertation: Computational Studies on R67 Dihydrofolate Reductase: An Investigation Into Its Unique Binding Patterns, Chuanyin Shi

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Dissertation: Analysis of N-Linked Oligosaccharides of Prostate-Specific Antigen and Prostatic Acid Phosphatase in Prostatic Fluids, Krista Yaudes White

Theses/Dissertations from 2008

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Dissertation: MALDI Mass Spectrometry Imaging for the Discovery of Prostate Carcinoma Biomarkers, Lisa Harris Cazares

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Dissertation: In Vivo Murine Melanoma Tumor Responses to Nanosecond Pulsed Electric Field Treatment, Xinhua Chen

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Dissertation: Nanosecond Pulsed Electric Fields Induce a Mitochondria-Independent Apoptosis in B16F10 Melanoma Cells In Vitro, Wentia Elissa Ford

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Dissertation: Subcellular Localization of Human T-cell Leukemia Virus Type 1 Tax Oncoprotein, Kimberly Anne Fryrear

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Dissertation: The Application of Innovative High-Throughput Techniques to Serum Biomarker Discovery, Izabela Debkiewicz Karbassi

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Dissertation: PGE2 Receptor Subsets Mediate HCG Regulation of the Plasminogen Activator/Plasmin System in Primate Periovulatory Follicles, Nune Markosyan

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Dissertation: Cannabinoids: A Novel Treatment Strategy for Retinal Neurodegenerative Disorders, Sandeep Samudre

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Dissertation: Gene Therapy Using Tet-Repressor System to Modulate Prostate Tumor Microenvironment, Nazita Yousefieh

Theses/Dissertations from 2007

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Dissertation: Down-Regulation of Natural Killer Cell Activation in Response to Influenza Virus in Older Adults, Yu Jing

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Dissertation: Serotype Association and Regulation of the Hyaluronate Lyase Gene of Streptococcus pyogenes, Martha Stokes

Theses/Dissertations from 2006

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Dissertation: Extracellular Superoxide Dismutase Protects Cardiomyocytes During Hyperoxia, Mervat Elsayed Ali

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Dissertation: Isolation and Functional Mapping of Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein DNA-Damage Complexes, Sarah Saionz Durkin

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Dissertation: Nanosecond Pulsed Electric Field Effects on Cell Cycle and Apoptosis, Emily H. Hall

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Dissertation: Structure-Function Studies of the cAMP-Dependent Protein Kinase In Vitro and in Intact Cells, Gary Z. Morris

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Dissertation: Modulation of TGFβ-Induced PAI -1 Expression by Changes in Actin Polymerization in Human Mesangial Cells, Keyur Patel

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Dissertation: Cellular Mechanism of Arglabin-Dimethylaminohydrochloride Cytotoxicity, Xiaofei Qin

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Dissertation: The Study of Nitric Oxide Synthase Expression, Function, and Regulation in the Renal Vasculature During Postnatal Renal Development, Brian Blake Ratliff

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Dissertation: The Use of Proteomic Technologies to Identify Serum Glycoproteins for the Early Detection of Liver and Prostate Cancers, Elizabeth Ellen Schwegler

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Dissertation: Diverse Effects of Nanosecond Pulsed Electric Fields on Mammalian Cells, Jody Anne White

Theses/Dissertations from 2005

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Dissertation: Mechanisms of Cell Death Initiated in Herpes Simplex Virus Thymidine Kinase Expressing Colon Tumor Cells Treated with Ganciclovir and UCN-01, Christina Elizabeth Ahn

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Dissertation: Regulation of SPARC Gene Expression by the Activator Protein 1 Transcription Factor, Joseph William Briggs

Dissertation: Defensin in the Ticks Dermacentor variabilis and Ixodes scapularis, Shane Michael Ceraul

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Dissertation: Developing and Optimizing Conditions for Single Cell Genetic Analysis, Susan Adele Gitlin

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Dissertation: Tumor Response TCF-4/β-Catenin Regulatory Elements for Enhancing Cancer Gene Therapies, Saurabh Kumar Gupta

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Dissertation: The Antitumor Agent, Arglabin-DMA, Preferentially Induces Apoptosis in Human Colon Tumor Cells, Sung Wook Kwon

Theses/Dissertations from 2004

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Dissertation: The Ultrastructure of the Olfactory System in Two Species of Short-Tailed Shrews, Blarina brevicauda and Blarina carolinensis, Lisa Johnson Byrum

Theses/Dissertations from 2003

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Dissertation: Characterization of Mouse Prostate Tumor-Infiltrating Leukocytes, Daniel Alan Holterman

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Dissertation: The Quantitative Assessment of Osteoinductivity of Human Demineralized Bone Matrix and cDNA Array Analysis of Osteogenic Differentiation in Human Periosteal Cells, Sittisak Honsawek

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Dissertation: Embryo and Gamete Development Upon Exposure to CCA Components: CrO3, CuO, and AS2O5, Nerbana Talaat-Elsebaei Mahmoud

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Thesis: Expression of Glutathione-S-Transferase MU 1 (GSTM1) and Glutathione-S-Transferase Theta 1 (GSTT1) in Patients with Aplastic Anemia and Myelodysplastic Syndromes, Aaron Conrad Spivey

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Dissertation: K+-Induced Smooth Muscle Calcium Sensitization Requires RhoA Kinase (ROK) Translocation to Caveolae Which Is Inhibited in Non-Neuronal Cell Memory, Nicole Hairrell Urban

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Dissertation: Hyaluronate Lyase Gene of Streptococcus pyogenes: Molecular Characterization and Regulation, Sheryl Lynne Walton

Theses/Dissertations from 2002

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Dissertation: Involvement of Platelet-Derived Growth Factor, PDGF Receptor Signaling, Focal Adhesion Kinase and SRC in Pressure-Induced Vascular Smooth Muscle Hypertrophy, Darian Clark Rice

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Dissertation: Apoptosis Pathways: Presence and significance in Ejaculated Human Spermatozoa, Steven Lewis Taylor

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Dissertation: Prostate Specific Membrane Antigen (PSMA): Immunoassay Development and Characterization of Transcriptional Regulation, Zhen Xiao

Theses/Dissertations from 2001

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Dissertation: Detection of Aneuploidy for Chromosomes 7 and 8 Using Fluorescence In Situ Hybridization in Patients with Aplastic Anemia and Sequencing of the Mitotic Checkpoint Gene hBUB1, Laura Jane Aridgides

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Dissertation: Characterization of Murine Cytomegalovirus m142 and m143 Essential Gene Products, Bridget Linette Dalton

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Dissertation: Estrogen Regulation of the Pregnant Baboon Placental 11β-Hydroxysteroid Dehydrogenase (11β-HSD)-Catalyzed Metabolism of Cortisol and Cortisone and Its Effect on the Development of the Fetal Hypothalamic-Pituitary-Adrenal Axis, William Adair Davies

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Dissertation: Regulation of the HCMV UL98 Promoter by Cooperation of the Cyclic AMP Response Element and Gamma Interferon Response Element, Tabmitha Patricia Young Jervey

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Dissertation: Interactions Among Murine Cytomegalovirus US22 Family Gene Products That Influence Viral Pathogenesis, Zaruhi Karabekian

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Dissertation: Characterization of the Biological Activities of Recombinant Fusion Protein Green Fluorescent Protein/Human Zona Pellucida Protein 3 (GFP/HZP3), Zhiyong Lin

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Dissertation: Characterization of the Human Cytomegalovirus UL75 Late Gene Promoter, Bernard J. P. McWatters

Theses/Dissertations from 2000

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Dissertation: Characterization of Human T-Cell Leukemia Virus 1 Reverse Transcriptase, Pinky Gundayao Agbuya

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Dissertation: Mechanistic Characterization of the Mitochondrial Type I DNA Topoisomerase and a Study of Genes Containing Type I DNA Topoisomerase-Related Domains, Jaydee Dones Cabral

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Dissertation: Role of Lipolysis and Lipogenesis in the Development of Diet-Induced Obesity, Michael John Davies

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Dissertation: Transcriptional Regulation of Chicken Apolipoprotein A-I Gene Expression, Wen Lin Kumfert

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Dissertation: Investigations on the Use of Ion Mobility Spectrometry for Clinical Chemistry Applications, Henri Parson Patten

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Dissertation: Telomerase Activity in Human Preimplantation Embryos, Diane Lynne Wright

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Dissertation: Human Gonadotropin-Releasing Hormone (hGnRH) Gene Expression and Hormone Regulation in Human Placental JEG-3 Cells, Heming Zheng

Theses/Dissertations from 1999

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Dissertation: Production of Copper-Complexing Ligands in Response to Elevated Concentrations of Copper in Marine Synechococcus spp., Arunsri Chatkaeomorakot Brown

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Dissertation: Construction of an Escherichia coli lac Repressor-Based System to Study Human Cytomegalovirus Gene Expression, Laura Fernanda Cageao-Luchetti

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Dissertation: Tissue-Specific Expression and Steroid Hormone Regulation of Human Gonadotropin -Releasing Hormone (hGnRH) Gene in Placental Cells (JEG -3 cells), Zhengguang Chen

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Dissertation: Identification and Characterization of Determinants of Head and Neck Tumor Cell Invasion, Yangguan Wu

Theses/Dissertations from 1998

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Dissertation: Expression, Isolation and Purification of Human Zona Pellucida Protein 3, Ting-Fung Chi

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Dissertation: Characterization of the Biological Functions of Human Recombinant Zona Pellucida Protein 3, Yu Wen Juan

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Dissertation: Pressure-Induced Intracellular Signaling in Isolated Arteries, Victor A. Miriel

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Dissertation: Leukemia Inhibitory Factor (LIF): Murine Preimplantation Embryo Development, Implantation Rates, and Skeletal Development, Michael Hayes Mitchell

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Dissertation: The Role of Glycoconjugates in Mediating Human Fertilization and Induction of Fetomaternal Tolerance, Manish S. Patankar

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Dissertation: Mouse Embryo Development in the Presence of Capsaicin, Carlos Santiago Villar-Gosalvez

Theses/Dissertations from 1997

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Dissertation: Differential Endometrial Responses of Primates vs Rodents: Screening for Antiproliferative Effects of Antiprogestins, David Williams Burleigh

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Dissertation: Fluorescence in Situ Hybridization Analysis of Human Embryos Derived From in Vitro and in Vivo Matured Oocytes, Constance DeScisciolo

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Dissertation: Choline Acetyltransferase and Carnitine Acetyltransferase Activity in Human Spermatozoa During Capacitation, Lisa A. Eccles

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Dissertation: Abnormalities in Post-Translational Processing of Platelet Rap 1B in NIDDM: A Possible Cause of Platelet Hyperactivity and Cardiovascular Disease in Diabetes, Elizabeth Ann Hall

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Dissertation: Interaction of ACTH and Estradiol in the Regulation of Growth, Differentiation, and Steroidogenic Maturation of the Baboon Fetal Adrenal Gland, Maria Gomez Leavitt

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Dissertation: The Cellular and Molecular Dynamics of the Queuosine Modification in Transfer RNA: Definition, Modulation, Deficiencies and Effect of the Queuosine Modification System, Rana C. Morris

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Dissertation: Characterization of the Fast Axonally Transported Proteins in the Rat Optic Pathway, Surafel Mulugeta

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Dissertation: Arterial Wall Hypertrophy and PDGF-A Expression in One-Kidney, One-Clip Hypertension and Angiotensin II Infusion Are Mediated By Elevated Arterial Pressure, Sheri Blair Parker

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Dissertation: Type II Estrogen Binding-Site Agonist: The Synthesis and Biological Evaluation of the Enantiomers of Methyl-Para-Hydroxyphenyllactate (MeHPLA), Lester G. Pretlow

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Dissertation: The Effects of Estrogen on Dorsal Root Ganglion Neurons, Sheila A. Scoville