Abstract/Description
Background: Cardiovascular risk and kidney function are interrelated, with variations by sex and age. Middle-aged women often have slightly lower kidney function than men, increasing susceptibility to early renal effects of elevated cardiovascular risk, but data from Latin America remain limited.
Methods: Cross-sectional study of adults aged 40-79 years evaluated at a tertiary hospital in Peru between January and June 2024. We excluded individuals with established cardiovascular disease, statin use, LDL >190 mg/dL, or incomplete ASCVD risk data. Ten-year ASCVD risk was estimated using the 2013 Pooled Cohort Equations with race set as “Other” and classified as low, borderline, intermediate, or high. eGFR was calculated with the 2021CKD-EPI equation, compared across ASCVD categories with Kruskal–Wallis test, and examined for trends using Spearman correlation. Multivariable linear models adjusted for age, sex, BMI, and systolic BP, with subgroup analyses by sex and age (< 60 vs ≥60 years).
Results: We included 207 participants (mean age 62.9 years, 54.6% women). Mean eGFR declined progressively across ASCVD categories (H = 40.79, p < 0.001) and inversely correlated with ASCVD risk (rho = –0.436, p < 0.001). Higher ASCVD risk remained independently associated with lower eGFR in adjusted models. The strongest effect was in women < 60 years, with each 1% ASCVD risk increase associated with –2.8 mL/min/1.73 m² lower eGFR (95% CI –5.37 to –0.23; p = 0.033).
Conclusion: In this Peruvian cohort, kidney function decreased with increasing cardiovascular risk, with a particularly pronounced effect in younger women, underscoring the need for early prevention in this group.
Faculty Advisor/Mentor
Johanna Contreras, MD, MSc, FACC, FAHA, FASE, FHFSA
Faculty Advisor/Mentor Email
johanna.contreras@mountsinai.org
Faculty Advisor/Mentor Department
Department of Cardiology, Mount Sinai Hospital, New York, NY, USA.
College/School/Affiliation
Eastern Virginia Medical School (EVMS)
Included in
Association Between Cardiovascular Risk and Kidney Function in a Real-World Peruvian Cohort
Background: Cardiovascular risk and kidney function are interrelated, with variations by sex and age. Middle-aged women often have slightly lower kidney function than men, increasing susceptibility to early renal effects of elevated cardiovascular risk, but data from Latin America remain limited.
Methods: Cross-sectional study of adults aged 40-79 years evaluated at a tertiary hospital in Peru between January and June 2024. We excluded individuals with established cardiovascular disease, statin use, LDL >190 mg/dL, or incomplete ASCVD risk data. Ten-year ASCVD risk was estimated using the 2013 Pooled Cohort Equations with race set as “Other” and classified as low, borderline, intermediate, or high. eGFR was calculated with the 2021CKD-EPI equation, compared across ASCVD categories with Kruskal–Wallis test, and examined for trends using Spearman correlation. Multivariable linear models adjusted for age, sex, BMI, and systolic BP, with subgroup analyses by sex and age (< 60 vs ≥60 years).
Results: We included 207 participants (mean age 62.9 years, 54.6% women). Mean eGFR declined progressively across ASCVD categories (H = 40.79, p < 0.001) and inversely correlated with ASCVD risk (rho = –0.436, p < 0.001). Higher ASCVD risk remained independently associated with lower eGFR in adjusted models. The strongest effect was in women < 60 years, with each 1% ASCVD risk increase associated with –2.8 mL/min/1.73 m² lower eGFR (95% CI –5.37 to –0.23; p = 0.033).
Conclusion: In this Peruvian cohort, kidney function decreased with increasing cardiovascular risk, with a particularly pronounced effect in younger women, underscoring the need for early prevention in this group.