Document Type

Article

Publication Date

2020

DOI

10.3389/fams.2020.00032

Publication Title

Frontiers in Applied Mathematics and Statistics

Volume

6

Pages

32 (1-16)

Abstract

Apraxia of speech is an impairment in the planning and programming of speech typically accompanied by aphasia (language impairment) secondary to a left hemisphere stroke. It is unknown if the structural and functional connections to the damaged area implicate the integrity of the cognitive functions of the prefrontal cortex (PFC). The present study examines the feasibility of measuring hemodynamic activity in the PFC in response to the structure of practice and during treatment. This multiple-baseline single case-design study involving two individuals with chronic acquired apraxia of speech measured the hemodynamic changes in PFC activity during treatment across the intervention period using functional near-infrared spectroscopy (fNIRS). Two models-a generalized linear model and a spatial varying coefficient model-are used to distinguish the repeated measures of PFC activity differences corresponding to the stage of practice and time of intervention. There were significant differences in the pattern of PFC activity associated with the structure of practice and the time of intervention. The outcomes from this pilot study demonstrate the utility of fNIRS to identify cognitive effort during speech motor learning. The implications include consideration for statistical methods used for fNIRS analysis and its potential use as a clinical tool to complement behavior changes to guide patient-directed intervention to optimize patient outcomes.

Comments

© 2020 Johnson, Matthews, Diawara and Carroll.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

https://creativecommons.org/licenses/by/4.0/

ORCID

0000-0003-2479-2965 (Johnson), 0000-0002-8403-6793 (Diawara)

Original Publication Citation

Johnson, R., Matthews, J., Diawara, N., & Carroll, R. (2020). Statistical analysis of fNIRS data: Consideration of spatial varying coefficient model of prefrontal cortex activity changes during speech motor learning in apraxia of speech. Frontiers in Applied Mathematics and Statistics, 6, 1-16, Article 32. https://doi.org/10.3389/fams.2020.00032

Download

Share

COinS