Date of Award

Spring 1997

Document Type


Degree Name

Master of Science (MS)


Chemistry & Biochemistry



Committee Director

Edward J. Poziomek

Committee Member

John B. Cooper

Committee Member

Roy L. Williams

Call Number for Print

Special Collections LD4331.C45 T357


The objective of this study is to develop analytical methods for studying contraband drugs at nanogram levels and to demonstrate the utility of the methods. A method which combines solid phase microextraction with ion mobility spectrometry (SPME-IMS) was developed. The SPME-IMS method was used as a rapid screening tool in studying the chemistry of cocaine HCI, heroin HCI, and heroin freebase on surfaces. The total time for sample preparation, reaction, and analysis is approximately seven minutes. Another method that was developed is one that combines solid phase microextraction with gas chromatography (SPME-GC) for the quantitative analysis of cocaine freebase and cocaine HCI. The SPME-GC headspace method was used to examine the conversion reactions of the drugs on candidate reactive surfaces.


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