Date of Award

Spring 1993

Document Type


Degree Name

Master of Science (MS)


Chemistry & Biochemistry



Committee Director

Patricia A. Pleban

Committee Member

Roy L. Williams

Committee Member

Laura K. Moen

Committee Member

Reuben Rohn

Call Number for Print

Special Collections LD4331.C45 F36


Most studies on the biological activity of selenium have focused on its role at the active site in the ubiquitous enzyme, glutathione peroxidase (GSH-Px) which catalyzes the removal of hydrogen peroxide and organic hydroperoxides (1). A connection between selenium deficiency and a wide range of diseases in animals and humans has been reviewed (2). Development of various forms of human cancer (3), failure of the immune system (4), as well as some cardiovascular diseases (5) have been reported or suspected to correlate with selenium deficiency. However, the physiological function of selenium in these different diseases is not fully understood, and the loss of glutathione peroxidase activity does not appear sufficient to explain the connection between selenium deficiency and the disease pathology (6).


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