ORCID

0009-0001-6550-298X (Olexson), 0009-0004-4995-841X (Vera), 0009-0000-3072-6732 (Ro), 0000-0002-6783-1904 (Enos)

Document Type

Article

Publication Date

2025

DOI

10.1002/jvc2.70265

Publication Title

JEADV Clinical Practice

Volume

Advance online publication

Pages

4 pp.

Abstract

[Introduction] Prurigo nodularis (PN) is a chronic neuroinflammatory dermatosis of unknown etiology characterized by severely pruritic, symmetrically-distributed nodules with a negative impact on quality of life [1]. While some consider PN a primary idiopathic disorder, it often arises as a secondary manifestation of underlying conditions, including atopic dermatitis (AD), chronic kidney disease (CKD), human-immunodeficiency-virus (HIV), and thyroid disorders [2]. Although patients with PN are at higher risk for psychiatric comorbidities including depression, anxiety, and suicidal ideation [3] research which investigates associations between PN and neurodegenerative disorders is limited [4]. Moreover, emerging evidence implicating sustained systemic inflammation, characteristic of psoriasis and AD, in the pathogenesis of dementias, particularly Alzheimer's, underscores the necessity of investigating whether inflammatory skin conditions like PN similarly influence the development of dementia [5, 6]. We conducted a large-scale, retrospective-cohort-study to assess the relationship between PN and dementia.

Rights

© 2025 The Authors.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Data Availability

Article states: "The data that support the findings of this study are available from the corresponding author upon reasonable request."

Original Publication Citation

Olexson, M. P., Ormaza Vera, A., Ro, C., & Enos, C. W. (2025). Dementia incidence in patients with prurigo nodularis: An observational retrospective cohort study. JEADV Clinical Practice. Advance online publication. https://doi.org/10.1002/jvc2.70265

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