Document Type
Article
Publication Date
2020
DOI
10.1038/s41598-020-74419-9
Publication Title
Scientific Reports
Volume
10
Issue
1
Pages
11 pp.
Abstract
A brain tumor is an uncontrolled growth of cancerous cells in the brain. Accurate segmentation and classification of tumors are critical for subsequent prognosis and treatment planning. This work proposes context aware deep learning for brain tumor segmentation, subtype classification, and overall survival prediction using structural multimodal magnetic resonance images (mMRI). We first propose a 3D context aware deep learning, that considers uncertainty of tumor location in the radiology mMRI image sub-regions, to obtain tumor segmentation. We then apply a regular 3D convolutional neural network (CNN) on the tumor segments to achieve tumor subtype classification. Finally, we perform survival prediction using a hybrid method of deep learning and machine learning. To evaluate the performance, we apply the proposed methods to the Multimodal Brain Tumor Segmentation Challenge 2019 (BraTS 2019) dataset for tumor segmentation and overall survival prediction, and to the dataset of the Computational Precision Medicine Radiology-Pathology (CPM-RadPath) Challenge on Brain Tumor Classification 2019 for tumor classification. We also perform an extensive performance evaluation based on popular evaluation metrics, such as Dice score coefficient, Hausdorff distance at percentile 95 (HD95), classification accuracy, and mean square error. The results suggest that the proposed method offers robust tumor segmentation and survival prediction, respectively. Furthermore, the tumor classification results in this work is ranked at second place in the testing phase of the 2019 CPM-RadPath global challenge.
Original Publication Citation
Pei, L., Vidyaratne, L., Rahman, M. M., & Iftekharuddin, K. M. (2020). Context aware deep learning for brain tumor segmentation, subtype classification, and survival prediction using radiology images. Scientific reports, 10(1), 11 pp., Article 19726. https://doi.org/10.1038/s41598-020-74419-9
Repository Citation
Pei, Linmin; Vidyaratne, Lasitha; Rahman, Md Monibor; and Iftekharuddin, Khan M., "Context Aware Deep Learning for Brain Tumor Segmentation, Subtype Classification, and Survival Prediction Using Radiology Images" (2020). Electrical & Computer Engineering Faculty Publications. 271.
https://digitalcommons.odu.edu/ece_fac_pubs/271
Comments
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.