Document Type

Article

Publication Date

2021

DOI

10.3390/life11080828

Publication Title

Life

Volume

11

Issue

8

Pages

828 (1-14)

Abstract

Biofilm infections in wounds seriously delay the healing process, and methicillin-resistant Staphylococcus aureus is a major cause of wound infections. In addition to inactivating micro-organisms, low-temperature gas plasma can restore the sensitivity of pathogenic microbes to antibiotics. However, the combined treatment has not been applied to infectious diseases. In this study, low-temperature gas plasma treatment promoted the effects of different antibiotics on the reduction of S. aureus biofilms in vitro. Low-temperature gas plasma combined with rifampicin also effectively reduced the S. aureus cells in biofilms in the murine wound infection model. The blood and histochemical analysis demonstrated the biosafety of the combined treatment. Our findings demonstrated that low-temperature gas plasma combined with antibiotics is a promising therapeutic strategy for wound infections.

Comments

This is an open access article distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Original Publication Citation

Guo, L., Yang, L., Qi, Y., Niyazi, G., Zheng, J., Xu, R., Chen, X., Zhang, J., Xi, W., Liu, D., Wang, X., Chen, H., & Kong, M. G. (2021). Low-temperature gas plasma combined with antibiotics for the reduction of methicillin-resistant Staphylococcus aureus biofilm both in vitro and in vivo. Life, 11(8), 1-14, Article 828. https://doi.org/10.3390/life11080828

ORCID

0000-0001-8142-4726 (Kong)

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