Document Type
Article
Publication Date
2025
DOI
10.1016/j.sbsr.2024.100732
Publication Title
Sensing and Bio-Sensing Research
Volume
47
Pages
100732 (1-11)
Abstract
MXenes are a novel type of nanostructured material that has received a lot of attention for their potential applications in bioanalysis owing to their unique features. These materials, made from transition metal nitrides, carbides, or carbonitrides, have a number of advantages, including high hydrophilicity, a large surface area, strong metallic conductivity, superior ion transport capabilities, biocompatibility, and low diffusion barriers. Their surfaces are easily manipulated, making them more adaptable for a variety of applications, including biosensing. The outstanding properties of MXenes have attracted researchers of different fields, including renewable energy, fuel cells, supercapacitors, electronics, and catalysis. In the context of biosensing, MXenes are particularly noteworthy because of their layered structure and composition, which render them suitable for both electrochemical and optical biosensors. The high electrical conductivity and multilayered design of MXenes facilitate effective charge transport and the preservation of biological activity when biomolecules are attached to their surfaces. This characteristic positions them as ideal candidates for the creation of sensitive and efficient electrochemical biosensors. Moreover, the inherent flexibility of MXenes allows for the development of sensors compatible with wearable technologies, presenting substantial opportunities for real-time, on-body detection of biomolecules. This review looks at various applications of MXenes in electrochemical and optical biosensing, with a focus on how they help improve sensor performance metrics like sensitivity, stability, and biocompatibility. It also discusses the obstacles and limitations that must be overcome to fully realize MXenes' potential in biosensor technology, such as issues with large-scale manufacturing, surface modification, and long-term stability. The review concludes by discussing future directions and advancements in this field.
Rights
© 2025 The Authors.
This is an open access article under the Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Data Availability
Article states: "Data will be made available on request."
Original Publication Citation
Amani, A. M., Tayebi, L., Vafa, E., Jahanbin, A., Abbasi, M., Vaez, A., Kamyab, H., Gnanasekaran, L., & Chelliapan, S. (2025). MXenes in biosensing: Enhancing sensitivity and flexibility – a review of properties, applications, and future directions. Sensing and Bio-Sensing Research, 47, 1-11, Article 100732. https://doi.org/10.1016/j.sbsr.2024.100732
Repository Citation
Amani, Ali Mohammad; Tayebi, Lobat; Vafa, Ehsan; Jahanbin, Alireza; Abbasi, Milad; Vaez, Ahmed; Kamyab, Hesam; Gnanasekaran, Lalitha; and Chelliapan, Shreeshivadasan, "MXenes in Biosensing: Enhancing Sensitivity and Flexibility - A Review of Properties, Applications, and Future Directions" (2025). Electrical & Computer Engineering Faculty Publications. 505.
https://digitalcommons.odu.edu/ece_fac_pubs/505
Included in
Biomedical Engineering and Bioengineering Commons, Electrical and Electronics Commons, Materials Science and Engineering Commons, Nanotechnology Commons
