Document Type

Article

Publication Date

2025

DOI

10.22034/nmbj.2025.538901.1081

Publication Title

Nano Micro Biosystems

Volume

4

Issue

3

Pages

26-32

Abstract

Nanoparticles (NPs), specifically polymer-modified NPs, have illustrated unique therapeutic advantages compared to bulk materials. Cellax NPs have provided a promising approach to cancer therapy by improving drug delivery, targeting the tumor microenvironment, and potentially overcoming drug resistance, all while reducing overall toxicity compared to traditional taxane treatment. By the flash nanoprecipitation (FNP) method, docetaxel and cabazitaxel have been formulated with polyethylene glycol (PEG) modified-acetylated carboxymethylcellulose (CMC) polymer to increase biocompatibility, bioavailability, specific targeting, and modulate the tumor microenvironment. However, there are some challenges and clinical limitations related to this formulation, encompassing optimum targeted delivery to tumors, overcoming biological barriers, such as the blood-brain barrier (BBB), and maintaining stability in vivo, which should be addressed in future studies. Treatment outcomes of some solid tumors, involving prostate, breast, pancreatic, melanoma, lung cancers, and hepatocellular carcinoma by Cellax NPs have been discussed in this mini-review article based on recent investigations.

Comments

As of December 2025, the DOI to this article, https://doi.org/10.22034/nmbj.2025.538901.1081, is non-functional.

Rights

© 2025 by the Authors.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) License.

Original Publication Citation

Tayebi, L., & Alavi, M. (2025). Cellax nanoparticles: Taxane nanoformulations for solid tumor targeting. Nano Micro Biosystems, 4(3), 26-32. https://www.nmb-journal.com/article_230850.html

ORCID

0000-0003-1947-5658 (Tayebi)

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