Document Type

Article

Publication Date

2023

DOI

10.3390/v15040937

Publication Title

Viruses

Volume

15

Issue

4

Pages

937 (1-22)

Abstract

In 2003, the United States saw an epidemic of monkeypox that was later traced back to rodents of West Africa infected with the monkeypox virus (MPXV). Disease in the United States seemed less severe than the smallpox-like disease in the Democratic Republic of the Congo (DRC). In this study, researchers analyzed data from Central Africa: two distinct MPXV clades were confirmed by sequencing the genomes of MPXV isolates from Western Africa, the United States, and Central Africa. By comparing open reading frames across MPXV clades, scientists can infer which virus proteins might account for the observed variation in pathogenicity in humans. Monkeypox can be prevented and controlled with a better understanding of MPXV’s molecular etiology and epidemiological and clinical features. In light of the current outbreaks worldwide, we provide updated information on monkeypox for medical professionals in this review.

Rights

© 2023 by the authors.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) License.

Data Availability

Article states: Data is available upon request from the corresponding authors.

ORCID

0000-0003-2824-4528 (Alla)

Original Publication Citation

Kumar, P., Chaudhary, B., Yadav, N., Devi, S., Pareek, A., Alla, S., Kajal, F., Nowrouzi-Kia, B., Chattu, V. K., & Gupta, M. M. (2023). Recent advances in research and management of human monkeypox virus: An emerging global health threat. Viruses, 15(4), 1-22, Article 937. https://doi.org/10.3390/v15040937

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