Document Type

Article

Publication Date

2025

DOI

10.1111/jch.70191

Publication Title

The Journal of Clinical Hypertension

Volume

27

Issue

12

Pages

e70191

Abstract

The Arterial Stiffness Index (AASI) is a calculation obtained through Ambulatory Blood Pressure Monitoring (ABPM), and is an indirect measure of the elastic properties of the arterial wall; but there is heterogeneity in its scope as a predictor of vascular wall health. A comparison is made between linear regression and exponential regression of the AASI, as well as an analysis of variance, according to circadian patterns and pulse pressure (PP) values. This work is an analytical observational study in 106 individuals, most of them women (63%) with a mean age of 53 ± 17.32 years. The coefficient of determination (r2) for the linear relationship was 0.53 ± 0.17, similar to the exponential relationship with an r(2) of 0.52 ± 0.17 (p = 0.7032). Patients with PP < 52 mmHg had an AASI of 0.3839 ± 0.1428 and for PP > 53 mmHg an AASI of 0.5330 ± 0.1108 (p < 0.0001). When comparing the AASI between Dipper vs. Riser circadian patterns, there was homoscedasticity (p = 0.3717); on the contrary, in the intergroup evaluation with Non-Dippers, heteroscedasticity was observed (Dipper vs. Non-Dipper; p = 0.0316 and Non-Dipper vs. Riser; p = 0.01978). This study concludes that the best determination of AASI is linear regression, robustly correlating with the values of PP > 53 mmHg and AASI > 0.5 (r = 0.9628). The behavior of the data in the Non-Dipper group is heterogeneous, probably due to their own physiological characteristics. In addition, AASI could be an indirect measure of arterial stiffness and be more directly associated with arterial elasticity and its deformation capacity.

Rights

© 2025 The Authors.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Data Availability

Article states: "The data supporting the findings of this study are openly available on DSpace at http://hdl.handle.net/10872/23236."

Original Publication Citation

Ayala-Hernández, J. R., López-Sánchez, C., Ayala, O. M., & Palencia-Tejedor, C. E. (2025). Ambulatory Arterial Stiffness Index: Regression method comparison and its association with pulse pressure and circadian patterns. Journal of Clinical Hypertension, 27(12), Article e70191. https://doi.org/10.1111/jch.70191

ORCID

0000-0003-0604-8606 (Ayala)

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