ORCID
0000-0001-6757-8905 (Bharadwaj), 0000-0002-1835-5390 (Lam)
Document Type
Article
Publication Date
2025
DOI
10.3390/allergies5040039
Publication Title
Allergies
Volume
5
Issue
4
Pages
39
Abstract
Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are common comorbid sinonasal conditions. CRS is classically divided into two distinct phenotypes: CRS with nasal polyposis (CRSwNP) and CRS without nasal polyposis (CRSsNP). The purpose of this retrospective observational study is to determine whether aeroallergen sensitization profiles in patients with comorbid CRS and AR can distinguish between CRSwNP and CRSsNP. A total of 241 patients diagnosed with comorbid CRS and AR who underwent skin prick testing or in vitro allergy testing in a single tertiary rhinology practice were included for evaluation. The rates of allergen-specific sensitizations in CRSwNP patients were compared with those in CRSsNP patients. Of the allergens tested in the routine panels, Dermatophagoides pteronyssinus (OR = 1.82, p = 0.03), Alternaria (OR = 2.55, p < 0.01), and animal dander (OR = 1.48 for cat and OR = 3.01 for dog, p < 0.01) were predictive of CRSwNP. Sensitization to any grass allergen was also predictive of CRSwNP (OR = 2.09, p < 0.01). Multiple perennial aeroallergens showed strong associations with CRSwNP; however, broad sensitization to perennial allergens as a whole group was not significantly predictive of CRSwNP (OR = 1.83, p = 0.22).
Rights
© 2025 by the authors.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Data Availability
Article states: "The original contributions presented in this study are included in the article. Further inquiries can be directed to the corresponding author."
Original Publication Citation
Trzcinski, L., Bharadwaj, S., Bloch, R. A., Han, J. K., & Lam, K. K. (2025). A comparison of allergen sensitization profiles in patients with chronic rhinosinusitis with and without nasal polyposis. Allergies, 5(4), Article 39. https://doi.org/10.3390/allergies5040039
Repository Citation
Trzcinski, L., Bharadwaj, S., Bloch, R. A., Han, J. K., & Lam, K. K. (2025). A comparison of allergen sensitization profiles in patients with chronic rhinosinusitis with and without nasal polyposis. Allergies, 5(4), Article 39. https://doi.org/10.3390/allergies5040039