ORCID

0000-0003-0060-1087 (Rubinstein)

Document Type

Article

Publication Date

2025

DOI

10.1017/S0022215125103915

Publication Title

Journal of Laryngology & Otology

Volume

Advance online publication

Pages

6 pp.

Abstract

Objectives

Explore the efficacy of tramadol for neurogenic cough and describe the longitudinal treatment experience.

Methods

A retrospective case series of adults with chronic cough who were treated with tramadol for neurogenic cough. A complete response was defined as no pathologic coughing, and a partial response was defined as 50% or greater reduction in severity or frequency.

Results

Sixty-nine patients were included. 38% of patients reported a complete response with an additional 33% reporting a partial response. The most common successful dosing regimen was 50 mg BID. Age, gender, and BMI did not impact treatment response. Patients with a history of laryngeal surgery were less likely to respond (p=0.04). Sedation (10%) was the most common side effect. Fifty percent of complete responders (n=13) were weaned off tramadol after a mean of 39 weeks of treatment.

Conclusion

Tramadol may be effective and is well tolerated in patients with neurogenic cough.

Rights

© The Authors 2025.

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.

Original Publication Citation

Rubinstein, B. J., Saidha, S., & Sinacori, J. T. (2025). Tramadol for treatment of neurogenic cough: A retrospective case series. Journal of Laryngology & Otology. Advance online publication. https://doi.org/10.1017/s0022215125103915 

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