Reply to: Malik MMUD on Early and Sustained Improvements in Sense of Smell With Tezepelumab Treatment in Patients With Chronic Rhinosinusitis With Nasal Polyps (WAYPOINT)

Authors

• Joaquim Mullol, University of Barcelona
• Joseph K. Han, Macon & Joan Brock Virginia Health Sciences at Old Dominion UniversityFollow
• Tanya M. Laidlaw, Harvard Medical School
• Claire Hopkins, Guy's and St. Thomas' Hospital
• Anju T. Peters, Northwestern University
• Oliver Pfaar, Philipps University of Marburg
• Martin Desrosiers, University of Montreal
• Stella E. Lee, Harvard Medical School
• Andrew P. Lane, Johns Hopkins School of Medicine
• Claudia Chen, AstraZeneca
• Yun Chon, Thousand Oaks

Document Type

Editorial

Publication Date

2026

DOI

10.1002/alr.70240

Publication Title

International Forum of Allergy & Rhinology

Volume

16

Issue

9

Pages

1060-1061

Abstract

[Introduction] To the Editor:

We thank Professor MMUD Malik [1] for his interest in our recent publication describing the improvements in loss of smell symptoms with tezepelumab versus placebo in patients with uncontrolled chronic rhinosinusitis with nasal polyps in the WAYPOINT trial (NCT04851964) [2]. We appreciate Professor Malik's comments on the language used to describe the findings and the specific analyses presented as well as his note regarding the consistent improvements in sense of smell observed with tezepelumab treatment versus placebo, demonstrated by large effect sizes across three instruments.

Rights

© 2026 The Authors.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Original Publication Citation

Mullol, J., Han, J. K., Laidlaw, T. M., Hopkins, C., Peters, A. T., Pfaar, O., Desrosiers, M., Lee, S. E., Lane, A. P., Chen, C., Chon, Y., Ponnarambil, S. S., Foster, A., Lindsley, A. W., & Ambrose, C. S. (2026). Reply to: Malik MMUD on early and sustained improvements in sense of smell with tezepelumab treatment in patients with chronic rhinosinusitis with nasal polyps (WAYPOINT). International Forum of Allergy & Rhinology, 16(9), 1060-1061. https://doi.org/10.1002/alr.70240

Repository Citation

Mullol, J., Han, J. K., Laidlaw, T. M., Hopkins, C., Peters, A. T., Pfaar, O., Desrosiers, M., Lee, S. E., Lane, A. P., Chen, C., Chon, Y., Ponnarambil, S. S., Foster, A., Lindsley, A. W., & Ambrose, C. S. (2026). Reply to: Malik MMUD on early and sustained improvements in sense of smell with tezepelumab treatment in patients with chronic rhinosinusitis with nasal polyps (WAYPOINT). International Forum of Allergy & Rhinology, 16(9), 1060-1061. https://doi.org/10.1002/alr.70240