Proposed Strategies to Increase the Likelihood of Achieving Remission in Chronic Rhinosinusitis with Nasal Polyps by European Forum for Research and Education in Allergy and Airway Diseases

Authors

• P. W. Hellings, KU Leuven, Leuven, Belgium
• S. E. Lee, University Hospitals Leuven
• E. De Corso, University of Perugia
• S. Alsaleh, Ministry of Interior, Riyadh, Saudi Arabia
• N. H. Alotaibi, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
• V. Backer, Copenhagen University, Copenhagen, Denmark
• M. A. Bader, Prince Mohammed Bin Abdulaziz Hospital
• X. Bertels, European Forum for Research and Education in Allergy and Airway Diseases Scientific Expert Team Members, Brussels, Belgium
• B. S. Bleier, Harvard Medical School
• Y. Chan, University of Toronto
• J. Constantinidis, AHEPA University Hospital
• D. M. Conti, KU Leuven, Leuven, Belgium
• M. E. Cornet, Alrijne Ziekenhuis, Leiderdorp, the Netherlands
• P. Gevaert, Ghent University
• J. Hagemann, Mainz University Medical Center
• J. Han, Macon & Joan Brock Virginia Health Sciences at Old Dominion UniversityFollow
• C. Hopkins, Guy's Hospital, London, United Kingdom
• D. E. Larenas-Linneman, Hospital Médica Sur, Tlalpan, México City
• V. J. Lund, University College London
• J. Mullol, Universitat de Barcelona
• A. T. Peters, Northwestern University Feinberg School of Medicine
• D. Rodiers, Department of Microbiology and Immunology
• G. K. Scadding, Royal National ENT Hospital London
• S. Schneider, Vienna General Hospital, Medical University of Vienna
• B. Senior, University of North Carolina
• W. J. Fokkens, University of Amsterdam

Document Type

Article

Publication Date

2026

DOI

10.1016/j.jaip.2026.09.016

Publication Title

The Journal of Allergy and Clinical Immunology: In Practice

Volume

14

Issue

11

Pages

2486-2491

Abstract

Remission in chronic rhinosinusitis with nasal polyps (CRSwNP) is considered the new aim of care given the reality of being able to achieve long-term disease control in patients with previously severe uncontrolled sinus disease after the combination of complete sinus surgery and long-term therapy with biologics. The state of remission helps patients to lead a normal life without a negative impact on well-being, saves costs for health care systems, and holds promise for future cure. The likelihood of patients with severe uncontrolled CRSwNP achieving remission after more than 18 months of therapy with biologics has been reported to be around 40% in real-life registries. Based on recent literature in CRSwNP and international consensus among European Forum for Research and Education in Allergy and Airway Diseases expert panel members, the health care community may consider several strategies that are likely to increase the number of patients with severe CRSwNP achieving remission. In this article we provide an overview of four strategic categories that may contribute alone or in combination to increasing the likelihood of patients with severe uncontrolled CRSwNP achieving remission. These are divided, albeit arbitrarily, into the categories of the health care system, the medical community, the therapeutic approach, and the patient community.

Rights

© 2026 The Authors.

This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.

Original Publication Citation

Hellings, P. W., Lee, S. E., De Corso, E., Alsaleh, S., Alotaibi, N. H., Backer, V., Bader, M. A., Bertels, X., Bleier, B. S., Chan, Y., Constantinidis, J., Conti, D. M., Cornet, M. E., Gevaert, P., Hagemann, J., Han, J., Hopkins, C., Larenas-Linneman, D. E., Lund, V. J.,…Fokkens, W. J. (2026). Proposed strategies to increase the likelihood of achieving remission in CRSwNP by EUFOREA. The Journal of Allergy and Clinical Immunology: In Practice, 14(11), 2486-2491. https://doi.org/10.1016/j.jaip.2026.09.016

Repository Citation

Hellings, P. W., Lee, S. E., De Corso, E., Alsaleh, S., Alotaibi, N. H., Backer, V., Bader, M. A., Bertels, X., Bleier, B. S., Chan, Y., Constantinidis, J., Conti, D. M., Cornet, M. E., Gevaert, P., Hagemann, J., Han, J., Hopkins, C., Larenas-Linneman, D. E., Lund, V. J.,…Fokkens, W. J. (2026). Proposed strategies to increase the likelihood of achieving remission in CRSwNP by EUFOREA. The Journal of Allergy and Clinical Immunology: In Practice, 14(11), 2486-2491. https://doi.org/10.1016/j.jaip.2026.09.016