College

College of Sciences

Department

Chemistry and Biochemistry

Graduate Level

Doctoral

Graduate Program/Concentration

Chemistry

Publication Date

2023

DOI

10.25883/3b6w-xr28

Abstract

Lack of early diagnosis, cancer recurrence, metastasis, and adverse side effects are some of the major problems in the treatment of cancers. Par-4, a tumor suppressor protein, is an attractive target for cancer therapy as it selectively kills cancer cells. Cl-Par-4 is the active fragment of Par-4 that enters the nucleus and selectively induces apoptosis in cancer cells. It has also been reported that Par-4 increases the susceptibility of cancer cells to chemotherapy and reverses cancer recurrence. Further, Par-4 has been shown to play a dual role: inhibition of EMT (Epithelial-mesenchymal transition) as well as assistance in the reverse process, thereby lowering the chance of cancer metastasis. Because of these unique properties of Par-4, it offers an attractive target for developing anticancer therapy. However, so far only the C-terminal coiled-coil domain has been studied structurally. Here, we have optimized conditions that will be helpful in the structural determination of cl-Par-4 using NMR and X-ray crystallography.

Keywords

Par-4, Tumor suppressor, Cancer therapy, Structural determination, NMR, Protein crystal

Disciplines

Biochemistry | Structural Biology

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Par-4: An Attractive Target for Cancer Therapy


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