College
College of Sciences
Department
Chemistry and Biochemistry
Graduate Level
Doctoral
Graduate Program/Concentration
Chemistry
Publication Date
2023
DOI
10.25883/3b6w-xr28
Abstract
Lack of early diagnosis, cancer recurrence, metastasis, and adverse side effects are some of the major problems in the treatment of cancers. Par-4, a tumor suppressor protein, is an attractive target for cancer therapy as it selectively kills cancer cells. Cl-Par-4 is the active fragment of Par-4 that enters the nucleus and selectively induces apoptosis in cancer cells. It has also been reported that Par-4 increases the susceptibility of cancer cells to chemotherapy and reverses cancer recurrence. Further, Par-4 has been shown to play a dual role: inhibition of EMT (Epithelial-mesenchymal transition) as well as assistance in the reverse process, thereby lowering the chance of cancer metastasis. Because of these unique properties of Par-4, it offers an attractive target for developing anticancer therapy. However, so far only the C-terminal coiled-coil domain has been studied structurally. Here, we have optimized conditions that will be helpful in the structural determination of cl-Par-4 using NMR and X-ray crystallography.
Keywords
Par-4, Tumor suppressor, Cancer therapy, Structural determination, NMR, Protein crystal
Disciplines
Biochemistry | Structural Biology
Files
Download Full Text (1.3 MB)
Recommended Citation
Raut, Krishna K.; Baudin, Antoine; Libich, David S.; Liu, Lijun; Lovell, Scott; and Pascal, Steven M., "Par-4: An Attractive Target for Cancer Therapy" (2023). College of Sciences Posters. 4.
https://digitalcommons.odu.edu/gradposters2023_sciences/4