ORCID

0009-0003-3263-2897 (Priessnitz), 0009-0009-6178-1377 (Hagopian), 0000-0001-8814-0259 (Patev), 0000-0002-1835-5390 (Lam)

Document Type

Article

Publication Date

2026

DOI

10.1002/clt2.70212

Publication Title

Clinical and Translational Allergy

Volume

16

Issue

10

Pages

e70212 (18 pp.)

Abstract

Background

Aspirin-exacerbated respiratory disease (AERD), also termed nonsteroidal anti-inflammatory drug exacerbated respiratory disease (NERD), is characterized by asthma, chronic rhinosinusitis with nasal polyposis, and hypersensitivity to cyclooxygenase-1 inhibitors, frequently resulting in severe, treatment-refractory airway disease. Biologic therapies targeting type 2 inflammation are increasingly used in AERD; though their relative efficacy remains incompletely defined.

Methods

We conducted a semi-systematic narrative review of biologic therapies in AERD, guided by established narrative review frameworks. PubMed/Medline, ScienceDirect, and ClinicalTrials.gov were searched for studies reporting clinical outcomes in AERD/NERD or clearly defined AERD/NERD subgroups. This review synthesizes current evidence and presents an evidence-informed clinical framework to support biologic selection in patients with AERD.

Results

Eighteen studies identified, including randomized controlled trials, observational studies, and real-world studies. Across these studies, dupilumab was most consistently associated with improvements in both upper and lower airway outcomes. Anti-IL-5 and anti-IL-5Rα therapies reduced eosinophilia and asthma exacerbations, with variable sinonasal benefit. Omalizumab demonstrated efficacy in selected atopic phenotypes and in conjunction with aspirin therapy following desensitization. Emerging subgroup data suggests that Tezepelumab may reduce asthma exacerbations in AERD.

Conclusions

Current evidence suggests biologic therapies provide meaningful benefit in AERD, although available evidence is limited by small sample sizes and heterogeneous designs. Prospective comparative studies are needed to inform optimal biologic selection and sequencing.

Rights

© 2026 The Authors

This is an open access article under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited.

Data Availability

Article states: "Data sharing not applicable to this article as no datasets were generated or analyzed during the current study."

Original Publication Citation

Priessnitz, J. K., Hagopian, A., Patev, A. J., Han, J. K., & Lam, K. K. (2026). Efficacy of biologics in aspirin exacerbated respiratory disease. Clinical and Translational Allergy, 16(10), Article e70212. https://doi.org/10.1002/clt2.70212

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