Document Type

Article

Publication Date

2025

DOI

10.7759/cureus.97536

Publication Title

Cureus

Volume

17

Issue

11

Pages

e97536

Abstract

Sarcoidosis is an inflammatory disease of unknown etiology that commonly involves multiple organ systems, with the lungs and lymph nodes most frequently affected. Osseous involvement, although recognized, is considered uncommon and often overlooked due to its nonspecific clinical and radiographic features. Patients may be asymptomatic or present with pain, swelling, and functional limitations of the affected limb. Imaging can reveal findings such as bone lesions that mimic malignancy, including lytic or sclerotic changes. Diagnosis relies on histopathological confirmation of non-caseating granulomas. Treatment is directed at symptom relief and preservation of limb function. Here, we present a rare case of isolated osseous sarcoidosis in a 38-year-old African American female that mimicked metastatic malignancy on imaging and responded dramatically to steroids.

Rights

© Copyright 2025 Ismail et al.

This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC-BY 4.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Original Publication Citation

Ismail, A., Saleh, A., & Boumber, Y. (2025). Sarcoidosis with isolated osseous manifestations mimicking metastatic malignancy. Cureus, 17(11), Article e97536. https://doi.org/10.7759/cureus.97536

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