ORCID
0009-0006-5465-2591 (D'Alessandro), 0000-0001-6014-9147 (Vippa), 0000-0001-7342-6481 (Oldfield)
Document Type
Article
Publication Date
2025
DOI
10.37349/edd.2025.1005107
Publication Title
Exploration of Digestive Diseases
Volume
4
Pages
1005107
Abstract
Diverticulitis is one of the most common gastrointestinal causes of hospitalization in Western society. While previously characterized as a disease of older patients, new literature highlights an increasing incidence among the younger population. Over the past few decades, the understanding of etiology and management of diverticulitis has changed drastically. New data refute past beliefs while promoting other novel recommendations to mitigate incidence and subsequent complications. Data now confirms the safety and possible protective benefit of particulate food, while highlighting evidence-based approaches for the use of diagnostic imaging and antibiotics. We recognize modifiable and non-modifiable risk factors that are commonly seen throughout the literature and play a significant role in the management and prevention of diverticulitis. Emerging evidence also links chronic inflammation with subsequent microbial dysbiosis and alterations in the neuroendocrine system, leading to visceral hypersensitivity and perturbation of the gut-brain axis. This review provides a comprehensive update on acute uncomplicated diverticulitis according to the most recent evidence-based literature, encompassing the risks, diagnostic modalities, and management treatment regimens.
Rights
© The Authors 2025
This is an Open Access article licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Data Availability
Article states: "Not Applicable."
Original Publication Citation
D’Alessandro, N. B., Vippa, T., Oldfield, E. C., IV, & Johnson, D. A. (2025). Diverticulitis—new evidence to share with patients. Exploration of Digestive Diseases, 4, Article 1005107. https://doi.org/10.37349/edd.2025.1005107
Repository Citation
D’Alessandro, N. B., Vippa, T., Oldfield, E. C., IV, & Johnson, D. A. (2025). Diverticulitis—new evidence to share with patients. Exploration of Digestive Diseases, 4, Article 1005107. https://doi.org/10.37349/edd.2025.1005107