Date of Award
Summer 8-2020
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Psychology
Program/Concentration
Virginia Consortium Program in Clinical Psychology
Committee Director
Robin Lewis
Committee Director
Jennifer Flaherty
Committee Member
Michael Stutts
Committee Member
Richard Handel
Committee Member
Matt Judah
Committee Member
Hamid Okhravi
Abstract
An estimated 5.8 million Americans suffer from dementia due to Alzheimer’s disease (AD), with that number projected to grow to 13.8 million by mid-century (Alzheimer’s Association, 2019). Mild cognitive impairment (MCI) describes the stage between normal cognitive decline that comes with aging and a dementia diagnosis (Peterson, 1999). Due to a lack of a cure or particularly effective treatment, a major goal of treatment is to focus on improving quality of life (Budson & Solomon, 2016). An early and accurate diagnosis can address this goal in a variety of ways. Despite the high prevalence and immense amount of research in MCI and AD, there is still no individual assessment measure that can definitively diagnose either. A multimodal approach must be implemented by clinicians and investigated by researchers to ensure early and accurate diagnosis. This study used multivariate logistic regression to analyze how two neuropsychological screening tests, two brain structures’ volumes, and an eye-tracking outcome all contributed to the diagnostic process. The two screening tests were the only unique contributors to the predictive model, and there was only slight evidence to suggest that the multimodal approach using these measures improved accuracy of diagnosis.
Rights
In Copyright. URI: http://rightsstatements.org/vocab/InC/1.0/ This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
DOI
10.25777/6tbv-wv04
ISBN
9798678108241
Recommended Citation
Flannery, Sean M..
"Investigating a Multimodal Approach to Clinical Diagnosis of Mild Cognitive Impairment and Alzheimer’s Disease"
(2020). Doctor of Philosophy (PhD), Dissertation, Psychology, Old Dominion University, DOI: 10.25777/6tbv-wv04
https://digitalcommons.odu.edu/psychology_etds/358
ORCID
0000-0002-5723-0654
Included in
Clinical Psychology Commons, Geriatrics Commons, Gerontology Commons
Comments
he VIRGINIA CONSORTIUM PROGRAM IN CLINICAL PSYCHOLOGY is a joint program of Eastern Virginia Medical School, Norfolk State University, and Old Dominion University.