Date of Award
Summer 1985
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Psychology
Program/Concentration
Psychology
Committee Director
Perry M. Duncan
Committee Member
Frederick G. Freeman
Committee Member
Peter J. Mikulka
Call Number for Print
Special Collections LD4331.P65A72
Abstract
The drug discrimination paradigm was used to investigate the effects of combinations of d-amphetamine sulfate (amph) and alcohol (etoh). Rats were trained to discriminate between the stimulus properties of 1.2 mg/kg amph and non-drug treatment in a two-lever food-motivated operant task. Once trained, rats were tested with .3 mg/kg amph, and showed an intermediate level of "amphetamine" responding. Combinations of this test dose with etoh 150 mg/kg or 300 mg/kg produced significantly increased amph-appropriate responding. This potentiation of the amph cue tended to be higher at etoh 150 mg/kg. The administration of etoh (150 or 300 mg/kg) alone did not result in amph-appropriate responding. These findings confirm earlier results from both drug discrimination and other behavioral paradigms, indicating that low doses of etoh in combination with low doses of amph can result in potentiation of amph effects.
Rights
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DOI
10.25777/d6bq-er79
Recommended Citation
Arango, Michaela.
"Effects of Ethanol on Stimulus Properties of D-Amphetamine"
(1985). Master of Science (MS), Thesis, Psychology, Old Dominion University, DOI: 10.25777/d6bq-er79
https://digitalcommons.odu.edu/psychology_etds/448