Date of Award

Summer 2004

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Psychology

Program/Concentration

Psychology

Committee Director

Perry M. Duncan

Committee Member

Peter J. Mikulka

Committee Member

Robin J. Lewis

Call Number for Print

Special Collections LD4331.P65 J662 2004

Abstract

The purpose of this experiment was to demonstrate the responses to stimuli predicting the onset of hypoglycemia {HG), specifically the overt behavioral and glycemic conditioned responses to insulin-produced HG. When drug-opposite compensatory responses become associated with situational and environmental cues that predict drug administration, compensatory mechanisms can be elicited solely by drugassociated cues. Several studies have been conducted to determine the conditioned bloodglucose responses as elicited by stimuli predicting hypoglycemia. However, only a few studies have examined the behavioral conditioned responses associated with hypoglycemia. Insulin-induced HG and the elevated plus maze (EPM) procedure were utilized to determine the direction of the conditioned glycemic, motor activity and anxiety responses in rat subjects. Rodents that received insulin prior to EPM testing demonstrated significantly high levels of anxious behavior and decreased activity during the later phases of testing. Although this study was able to demonstrate the unconditioned effects of hypoglycemia on activity and anxiety, it was unable to detect the presence of a conditioned behavioral or physiological response. The level of activity and time in open arms decreased as a function of amount of testing time. Thus, habituation-related changes in open-arm time and activity levels may have prevented detection of conditioned responses as indicated by these behavioral measures.

Rights

In Copyright. URI: http://rightsstatements.org/vocab/InC/1.0/ This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).

DOI

10.25777/0mmz-2d27

Download

Share

COinS