Date of Award

Summer 1982

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Psychology

Program/Concentration

Psychology

Committee Director

Frederick G. Freeman

Committee Member

Peter J. Mikulka

Committee Member

Perry M. Duncan

Call Number for Print

Special Collections LD4331.P65J37

Abstract

Three experiments were conducted to investigate the effects of naloxone hydrochloride on the seizure parameters (after discharge and motor seizure thresholds and durations) and post-ictal depression in kindled seizures. In Experiment 1, eight male hooded rats were exposed to four naloxone doses {2, 5, 10 mg/kg and a saline control) during a threshold testing procedure. In this factorial design, naloxone was found to have no effect on either the basic seizure parameters or post-ictal depression. Experiment 2 examined the effects of both naloxone dosage and inter­ stimulation interval (ISI) on kindled seizures. Eight male hooded rats were exposed to factorial combination of two ISIs (30 and 60 sec) and three naloxone doses (2, 10 mg/kg and a saline control) during a threshold testing procedure. Naloxone was found to significantly shorten motor seizure duration and postictal depression. Experiment 3 examined the effects of naloxone on a subsequent suprathreshold stimulation induced seizure following an initial suprathreshold stimulation. A factorial combination of four naloxone doses (2, 5, 10 mg/kg and a saline control) and two ISIs (2 and 6 min) separating the two stimulations was employed, While no main effects for either naloxone or ISI were found in the subsequent seizure activity, there was a significant interaction between naloxone and ISI for the subsequent motor seizure duration. It can be concluded from the results of the present experiments that the direction and consistency of naloxone's effects on kindled seizures remain unclear. However, the effects of ISI on seizure activity were found to be consistent with the previous literature, The role of endorphin as a possible mediator of post-ictal depression in kindled seizures does not appear primary, Differences in seizure severity between the kindling model and other drug models were discussed.

Rights

In Copyright. URI: http://rightsstatements.org/vocab/InC/1.0/ This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).

DOI

10.25777/12f7-e534

Download

Included in

Psychology Commons

Share

COinS