Date of Award

Fall 1996

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Psychology

Program/Concentration

Psychology

Committee Director

Perry M. Duncan

Committee Member

Frederick G. Freeman

Committee Member

Thomas F. Cash

Call Number for Print

Special Collections LD4331.P65 K626

Abstract

The present study investigated the effects of ethanol on insulin-induced hypoglycemia in rats. Measurements were made on the interaction of insulin at a dose of 2 units/kilogram in combination with four ethanol doses on motor activity and on blood glucose levels. Nine rats were administered eight treatment conditions (insulin or no insulin; combined with ethanol dosage of either: 0, 300, 600, or 1000 mg/kg). In a counterbalanced sequence of treatments, the rats were injected with insulin and placed into activity detectors for 20 minutes. At this time their blood glucose was measured, they were injected with ethanol, and placed hack into the activity detectors for 60 minutes. Blood glucose was again measured after the 60 minutes had elapsed. Insulin caused a decrease in motor activity both prior to and after ethanol injections. Without insulin a dose of 1000 mg/kg of ethanol was required to significantly decrease activity. However, with insulin pre-treatment, significant decreases were seen at 300 mg/kg and higher doses of ethanol. Insulin decreased blood glucose before and after ethanol injections, but ethanol did not influence blood glucose levels, nor did it interact with the insulin produced hypoglycemia.

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DOI

10.25777/6a3s-jm98

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