Date of Award

Fall 1990

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Psychology

Program/Concentration

Psychology

Committee Director

Perry M. Duncan

Committee Member

Frederick G. Freeman

Committee Member

Peter J. Mikulka

Call Number for Print

Special Collections LD4331.P65P48

Abstract

Male Long-Evans rats were conditioned 6 days, alternating drug and non-drug conditions, using injections of .6 mg/kg d-amphetamine, amphetamine plus 60mg/kg ethanol, or amphetamine plus 120 mg/kg ethanol. These injections were given in a specific side of the shuttlebox to assess the development of a place preference or aversion. The amount of time spent in the drug-paired side was analyzed on 2 non-drugged test days. Rats spent significantly more time in the drug-paired side on Test Day 1 than on Test Day 2. When the ethanol groups were combined, these rats spent significantly more time in the drug-paired side than did SAL or DA rats. When tested in the drugged condition, amphetamine-treated rats were significantly more active than when tested on the non-drugged condition days. Ethanol did not facilitate the amphetamine effect. Ethanol potentiated the reinforcing effect of amphetamine as evidenced by the CPP paradigm, and did not antagonize or potentiate amphetamine-induced locomotor activity.

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DOI

10.25777/n7sv-tk50

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