Differential Gene Expression in Chondrocytes Exposed to Simulated Microgravity
Description/Abstract/Artist Statement
Human articular cartilage responds to mechanical load through the extracellular matrix (ECM) components proteoglycans, glycoproteins, collagen fibers, and water. The extracellular matrix is produced by chondrocytes that metabolically regulate the synthesis and degradation of matrix for homeostasis. When astronauts are exposed to microgravity mechanical unloading occurs increasing the likelihood of cartilage degeneration. Currently, mechanisms of cartilage degeneration due to loss of gravity are unknown. The objective of this project is to determine differential expression of cartilage related genes in chondrocytes in order to identify mechanisms of cartilage degeneration. Knowledge of these mechanisms is important for determining factors initiating cartilage damaging diseases.
Presentation Type
Event
Location
Learning Commons @ Perry Library, Northwest Atrium
Start Date
2-18-2017 8:00 AM
End Date
2-18-2017 12:30 PM
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Differential Gene Expression in Chondrocytes Exposed to Simulated Microgravity
Learning Commons @ Perry Library, Northwest Atrium
Human articular cartilage responds to mechanical load through the extracellular matrix (ECM) components proteoglycans, glycoproteins, collagen fibers, and water. The extracellular matrix is produced by chondrocytes that metabolically regulate the synthesis and degradation of matrix for homeostasis. When astronauts are exposed to microgravity mechanical unloading occurs increasing the likelihood of cartilage degeneration. Currently, mechanisms of cartilage degeneration due to loss of gravity are unknown. The objective of this project is to determine differential expression of cartilage related genes in chondrocytes in order to identify mechanisms of cartilage degeneration. Knowledge of these mechanisms is important for determining factors initiating cartilage damaging diseases.
Comments
Mentor: Dr. Michael Stacey
Biological Sciences