Description/Abstract/Artist Statement
Nitrogen heterocycles are ubiquitous motifs which occur as the core structure of several alkaloid natural products exhibiting inherent biological activity against an array of bacteria, fungi, viruses, and cancer cell lines. These azacycles serve as key synthetic building blocks for medicinal chemists to access more structurally complex and diverse compounds with tunable biological properties. A synthetic approach to these valuable motifs employing intramolecular borrowing hydrogen catalysis has been developed. The utility of the developed chemistry will be applied to synthetic efforts towards the recently isolated Cylicomorphins A-E.
Faculty Advisor/Mentor
Kyle Lambert
College Affiliation
College of Sciences
Presentation Type
Poster
Disciplines
Organic Chemistry
Session Title
Poster Session
Location
Learning Commons @ Perry Library
Start Date
3-19-2022 9:00 AM
End Date
3-19-2022 11:00 AM
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Access to Nitrogen Heterocycles via Borrowing Hydrogen Catalysis
Learning Commons @ Perry Library
Nitrogen heterocycles are ubiquitous motifs which occur as the core structure of several alkaloid natural products exhibiting inherent biological activity against an array of bacteria, fungi, viruses, and cancer cell lines. These azacycles serve as key synthetic building blocks for medicinal chemists to access more structurally complex and diverse compounds with tunable biological properties. A synthetic approach to these valuable motifs employing intramolecular borrowing hydrogen catalysis has been developed. The utility of the developed chemistry will be applied to synthetic efforts towards the recently isolated Cylicomorphins A-E.