Borylation of Thioethers
Description/Abstract/Artist Statement
Late-stage functionalization of natural products and pharmaceuticals use CH functionalization to diversify the complex motif late in the synthesis accessing a large number of complex derivatives in a single step. Within CH functionalization, CH borylation is actively investigated due to the use of boronic acids and boronic esters in Suzuki coupling. Within the pharmaceutical industry, Suzuki coupling is one of the most frequently used transformations. However, regioselectivity of the CH borylation reaction remains a challenge to the field. Organosulfur molecules have a prominent role in drug therapies. More specifically, thioethers and other sulfur moieties make up a quarter of small-molecule pharmaceuticals. However, there is a lack of information about thioethers and the selectivity of CH borylations with these compounds. This project aims to synthesize thioethers and investigate their selectivity towards CH borylation as well as develop a regioselective CH borylation using the thioethers.
Faculty Advisor/Mentor
Dr. Kyle Lambert
Faculty Advisor/Mentor Department
Chemistry Department
College Affiliation
College of Sciences
Presentation Type
Oral Presentation
Disciplines
Organic Chemistry
Session Title
College of Sciences Presentations
Location
Learning Commons @Perry Library, Room 1310
Start Date
3-25-2023 12:00 PM
End Date
3-25-2023 1:00 AM
Borylation of Thioethers
Learning Commons @Perry Library, Room 1310
Late-stage functionalization of natural products and pharmaceuticals use CH functionalization to diversify the complex motif late in the synthesis accessing a large number of complex derivatives in a single step. Within CH functionalization, CH borylation is actively investigated due to the use of boronic acids and boronic esters in Suzuki coupling. Within the pharmaceutical industry, Suzuki coupling is one of the most frequently used transformations. However, regioselectivity of the CH borylation reaction remains a challenge to the field. Organosulfur molecules have a prominent role in drug therapies. More specifically, thioethers and other sulfur moieties make up a quarter of small-molecule pharmaceuticals. However, there is a lack of information about thioethers and the selectivity of CH borylations with these compounds. This project aims to synthesize thioethers and investigate their selectivity towards CH borylation as well as develop a regioselective CH borylation using the thioethers.