Patterns of Activation and Repression for a Single Transcription Factor with Multiple Binding Sites
Location
Old Dominion University, Learning Commons at Perry Library, West Foyer
Start Date
4-8-2017 8:30 AM
End Date
4-8-2017 10:00 AM
Description
The molecular complexity of eukaryotic gene regulation has made it difficult to study gene products, which are processed from DNA sequences. We built mathematical models of gene expression based on the established linear framework. In this project, we study how complicated the gene expression profile can be when a single type of transcription factor binds to multiple sites. The lambda phage repressor is a classical example of an actual gene that has both “activation” and “repression.” We investigate the parameters of the gene regulation functions (GRFs), such as higher-order affinity binding and cooperativity of TFs and polymerase. We gained insights to the GRFs’ behavior though (1) random exploration, (2) clustering parameters based on the characteristics of the GRFs, and (3) modular exploration.
Presentation Type
Poster
Patterns of Activation and Repression for a Single Transcription Factor with Multiple Binding Sites
Old Dominion University, Learning Commons at Perry Library, West Foyer
The molecular complexity of eukaryotic gene regulation has made it difficult to study gene products, which are processed from DNA sequences. We built mathematical models of gene expression based on the established linear framework. In this project, we study how complicated the gene expression profile can be when a single type of transcription factor binds to multiple sites. The lambda phage repressor is a classical example of an actual gene that has both “activation” and “repression.” We investigate the parameters of the gene regulation functions (GRFs), such as higher-order affinity binding and cooperativity of TFs and polymerase. We gained insights to the GRFs’ behavior though (1) random exploration, (2) clustering parameters based on the characteristics of the GRFs, and (3) modular exploration.