The Regulation of DNA Methylation by the HOXA13 gene within Glioblastoma Cells
Location
Taylor 405, Madison Union, JMU
Start Date
4-6-2019 9:00 AM
Description
Funded through a grant provided by the national Tri-Beta biology honors program, this project not only provides a potential way of controlling tumor progression, but it also delivers a possibility of how DNA methylation rates can be used to understand brain cancer. Using techniques such as human cell culture, western blotting, methylated DNA quantification, and CRISPR/CAS9, the project looks into the specific mechanism of hyper-methylation. Previously published literature linked homeobox genes to brain cancer (glioblastoma), but it was unclear why the two had a correlation. This project proposes that the missing link is the DNA methylation happening within the cells controlled by homeobox genes.
Presentation Type
Poster
The Regulation of DNA Methylation by the HOXA13 gene within Glioblastoma Cells
Taylor 405, Madison Union, JMU
Funded through a grant provided by the national Tri-Beta biology honors program, this project not only provides a potential way of controlling tumor progression, but it also delivers a possibility of how DNA methylation rates can be used to understand brain cancer. Using techniques such as human cell culture, western blotting, methylated DNA quantification, and CRISPR/CAS9, the project looks into the specific mechanism of hyper-methylation. Previously published literature linked homeobox genes to brain cancer (glioblastoma), but it was unclear why the two had a correlation. This project proposes that the missing link is the DNA methylation happening within the cells controlled by homeobox genes.