Crystal Structure of Glutamate--tRNA Synthase from Elizabethkingia anophelis and Elizabethkingia meningoseptica
Date
April 2021
Location
Online
Description
The United States has seen increased rates of infection for Gram-negative bacteria Elizabethkingia in the past ten years and discovering possible drugs to inhibit Elizabethkingia bacteria is of great public health importance. The Seattle Structural Genomics Center for Infectious Disease (SSGCID) has determined the structures of glutamate tRNA ligase from Elizabethkingia meningoseptica and Elizabethkingia anophelis. Similarities in structure and function to that of a protein with known drug inhibitors, glutamyl-tRNA synthetase GluRS from Pseudomonas aeruginosa, suggesting that these two proteins can be investigated further for drug discovery.
Presentation Type
Presentation
Crystal Structure of Glutamate--tRNA Synthase from Elizabethkingia anophelis and Elizabethkingia meningoseptica
Online
The United States has seen increased rates of infection for Gram-negative bacteria Elizabethkingia in the past ten years and discovering possible drugs to inhibit Elizabethkingia bacteria is of great public health importance. The Seattle Structural Genomics Center for Infectious Disease (SSGCID) has determined the structures of glutamate tRNA ligase from Elizabethkingia meningoseptica and Elizabethkingia anophelis. Similarities in structure and function to that of a protein with known drug inhibitors, glutamyl-tRNA synthetase GluRS from Pseudomonas aeruginosa, suggesting that these two proteins can be investigated further for drug discovery.