Document Type
Article
Publication Date
2020
Publication Title
Case Reports in Endocrinology
Volume
2020
Pages
4239679 (1-8)
DOI
10.1155/2020/4239679
Abstract
Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exceptionally rare. In this report, we describe a 66-year-old man with long-standing type 2 DM who presented with recurrent episodes of diaphoresis due to severe hypoglycemia despite the withdrawal of insulin therapy, hypercalcitoninemia, and biochemical and radiological findings suggestive of metastatic malignant insulinoma. Unfortunately, after few days of diazoxide treatment, edema, hypotension, oliguria, and water retention were observed, patient’s clinical status deteriorated rapidly, and he died in our department from acute renal failure.
Original Publication Citation
Ciacciarelli, M., Caruso, G., Rengo, M., ... Sorrentino, V., Petrozza, V., & Iuliano, L. (2020). Malignant insulinoma with multiple liver metastases and hypercalcitoninemia in a patient with type 2 diabetes mellitus presenting as recurrent episodes of diaphoresis due to severe hypoglycemia. Case Reports in Endocrinology, 2020, 1-8, Article 4239679. https://doi.org/10.1155/2020/4239679
Repository Citation
Ciacciarelli, Marco; Caruso, Gianluca; Rengo, Marco; Maceroni, Piero; Misurale, Carmen; D'Armiento, Eleonora; Napoli, Cristina; Lombardini, Alberto; Ceratti, Umberto; Luciano Colunga Biancatelli, Ruben Manuel; Calvosa, Leonardo; Milanese, Romina; Ferri, Sonia; Massaro, Teresa; Larusso, Andrea; Sorrentino, Veronica; and Petrozza, Vincenzo, "Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia" (2020). Bioelectrics Publications. 332.
https://digitalcommons.odu.edu/bioelectrics_pubs/332
ORCID
0000-0002-1174-3876 (Colunga Biancatelli)
Included in
Endocrine System Commons, Endocrinology, Diabetes, and Metabolism Commons, Hemic and Lymphatic Diseases Commons
Comments
Copyright © 2020 Marco Ciacciarelli et al.
This is an open access article distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.