Document Type

Article

Publication Date

2020

Publication Title

Case Reports in Endocrinology

Volume

2020

Pages

4239679 (1-8)

DOI

10.1155/2020/4239679

Abstract

Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exceptionally rare. In this report, we describe a 66-year-old man with long-standing type 2 DM who presented with recurrent episodes of diaphoresis due to severe hypoglycemia despite the withdrawal of insulin therapy, hypercalcitoninemia, and biochemical and radiological findings suggestive of metastatic malignant insulinoma. Unfortunately, after few days of diazoxide treatment, edema, hypotension, oliguria, and water retention were observed, patient’s clinical status deteriorated rapidly, and he died in our department from acute renal failure.

Comments

Copyright © 2020 Marco Ciacciarelli et al.

This is an open access article distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Original Publication Citation

Ciacciarelli, M., Caruso, G., Rengo, M., ... Sorrentino, V., Petrozza, V., & Iuliano, L. (2020). Malignant insulinoma with multiple liver metastases and hypercalcitoninemia in a patient with type 2 diabetes mellitus presenting as recurrent episodes of diaphoresis due to severe hypoglycemia. Case Reports in Endocrinology, 2020, 1-8, Article 4239679. https://doi.org/10.1155/2020/4239679

ORCID

0000-0002-1174-3876 (Colunga Biancatelli)

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