Document Type

Article

Publication Date

6-1989

DOI

10.1007/BF01114685

Publication Title

Bioscience Reports

Volume

9

Issue

3

Pages

329-340

Abstract

Several cell surface proteins (Mr = 120,000, 90,000, 63,000 and 47,000) apparently integral to embryonic fibroblast plasma membranes were extracted with detergent and isolated by collagen affinity chromatography. Certain of these proteins (Mr = 120,000, 90,000, and 47,000) were specifically eluted from collagen affinity columns by synthetic peptides containing the amino acid sequence arginyl-glycyl-aspartic acid (RGD). These data show that a number of collagen binding proteins exist on the embryonic fibroblast cell surface. Some of the proteins may be collagen receptors binding to RGD sequences in the collagen molecule while at least one of the proteins (Mr = 63,000) recognizes features other than RGD.

Original Publication Citation

Ogle, R.C., & Little, C.D. (1989). Collagen binding proteins derived from the embryonic fibroblast cell surface recognize arginine-glycine-aspartic acid. Bioscience Reports, 9(3), 329-340. doi: 10.1007/BF01114685

ORCID

0000-0002-4231-9488 (Ogle)