A selection of faculty publications from the School of Medical Diagnostics and Translational Sciences, College of Health Sciences, Old Dominion University.

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Submissions from 2024

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HSP70 is a Critical Regulator of HSP90 Inhibitor's Effectiveness in Preventing HCL-Induced Chronic Lung Injury and Pulmonary Fibrosis, Ruben M. L. Colunga Biancatelli, Pavel A. Solopov, Tierney Day, Betsy Gregory, Michael Osei-nkansah, Christiana Dimitropoulou, and John D. Catravas

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Synergistic Effects of Nanosecond Pulsed Plasma and Electric Field on Inactivation of Pancreatic Cancer Cells In Vitro, Edwin A. Oshin, Zobia Minhas, Ruben M. L. Colunga Biancatelli, John D. Catravas, Richard Heller, Siqi Guo, and Chunqi Jiang

Submissions from 2023

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Identification of Proteins Involved in Cell Membrane Permeabilization by Nanosecond Electric Pulses (nsEP), Giedre Silkuniene, Uma Mangalanathan, Alessandra Rossi, Peter A. Mollica, Andrei G. Pakhomov, and Olga N. Pakhomova

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Combined 3D Bioprinting and Tissue-Specific ECM System Reveals the Influence of Brain Matrix on Stem Cell Differentiation, Martina Zamponi, Peter A. Mollica, Yara Khodour, Julie S. Bjerring, Robert D. Bruno, and Patrick C. Sachs

Submissions from 2022

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NPGREAT: Assembly of the Human Subtelomere Regions with the Use of Ultralong Nanopore Reads and Linked Reads, Eleni Adam, Desh Ranjan, and Harold Riethman

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HSP90 Inhibitors Modulate SARS-CoV-2 Spike Protein Subunit 1-Induced Human Pulmonary Microvascular Endothelial Activation and Barrier Dysfunction, Ruben Manuel Luciano Colunga Biancatelli, Pavel Solopov, Betsy W. Gregory, Yara Khodour, and John D. Catravas

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Optimizing Antidotal Treatment with the Oral HSP90 Inhibitor TAS-116 Against Hydrochloric Acid-Induced Pulmonary Fibrosis in Mice, Pavel A. Solopov, Ruben Manuel Luciano Colunga Biancatelli, Christiana Dimitropolou, Tierney Day, and John Catravas

Submissions from 2021

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Analysis of Subtelomeric REXTAL Assemblies Using QUAST, Tunazzina Islam, Desh Ranjan, Mohammad Zubair, Eleanor Young, Ming Xiao, and Harold Riethman

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Dietary Phytoestrogens Ameliorate Hydrochloric Acid-Induced Chronic Lung Injury and Pulmonary Fibrosis in Mice, Pavel Solopov, Ruben Manuel Luciano Colunga Biancatelli, Christiana Dimitropoulou, and John D. Catravas

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Picosecond Pulsed Electric Fields and Promise in Neurodegeneration Research, Martina Zamponi, Ross Petrella, and Peter A. Mollica

Submissions from 2020

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Single-Molecule Analysis of Subtelomeres and Telomeres in Alternative Lengthening of Telomeres (ALT) Cells, Heba Z. Abid, Jennifer McCaffrey, Kaitlin Raseley, Eleanor Young, Katy Lassahn, Dharma Varapula, Harold Riethman, and Ming Xiao

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Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19), Ruben Manuel Luciano Colunga Biancatelli, Max Berrill, John D. Catravas, and Paul Ellis Marik

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Comprehensive Analysis of Human Subtelomeres by Whole Genome Mapping, Eleanor Young, Heba Z. Abid, Pui-Yan Kwok, Harold Riethman, and Ming Xiao

Submissions from 2019

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The Revolution Will Be Open-Source: How 3D Bioprinting Can Change 3D Cell Culture, Robert D. Bruno, John Reid, and Patrick C. Sachs

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A 3D Bioprinter Platform for Mechanistic Analysis of Tumoroids and Chimeric Mammary Organoids, John A. Reid, Xavier-Lewis Palmer, Peter A. Mollica, Nicole Northam, Patrick C. Sachs, and Robert D. Bruno

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Nanosecond Pulsed Electric Fields Induce Endoplasmic Reticulum Stress Accompanied by Immunogenic Cell Death in Murine Models of Lymphoma and Colorectal Cancer, Alessandra Rossi, Olga N. Pakhomova, Peter A. Mollica, Maura Casciola, Uma Mangalanathan, Andrei G. Pakhomov, and Claudia Muratori

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Mechanisms and Immunogenicity of nsPEF-Induced Cell Death in B16F10 Melanoma Tumors, Alessandra Rossi, Olga N. Pakhomova, Andrei G. Pakhomov, Samantha Weygandt, Anna A. Bulysheva, Len E. Murray, Peter A. Mollica, and Claudia Muratori

Submissions from 2018

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Wild-Type p53 Enhances Endothelial Barrier Function by Mediating RAC1 Signalling and RhoA Inhibition, Nektarios Barabutis, Christiana Dimitropoulou, Betsy Gregory, and John D. Catravas

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Electrotransfer of Different Control Plasmids Elicits Different Antitumor Effectiveness in B16.F10 Melanoma, Masa Bosnjak, Tanjo Jesenko, Urska Kamensek, Gregor Sersa, Jaka Lavrencak, Loree Heller, and Maja Cemazar

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Direct Crystal Formation from Micronized Bone and Lactic Acid: The Writing on the Wall for Calcium-Containing Crystal Pathogenesis in Osteoarthritis?, Anna A. Bulysheva, Nardos Sori, and Michael P. Francis

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Coordination of Different Ligands to Copper(II) and Cobalt(III) Metal Centers Enhances Zika Virus and Dengue Virus Loads in Both Arthropod Cells and Human Keratinocytes, Shovan Dutta, Michael J. Celestine, Supreet Khanal, Alexis Huddleston, Colin Simms, Jessa Faye Arca, Amlam Mitra, Loree Heller, Piotr Kraj, Michael Ledizet, John F. Anderson, Girish Neelakanta, Alvin A. Holder, and Hameeda Sultana

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Epigenetic Alterations Mediate iPSC Normalization of DNA-Repair Expression and TNR Stability in Huntington's Disease, Peter A. Mollica, Martina Zamponi, John Reid, Deepak Sharma, Alyson E. White, Roy C. Ogle, Robert D. Bruno, and Patrick C. Sachs

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Pneumatospinning of Collagen Microfibers From Benign Solvents, Seth Polk, Nardos Sori, Nick Thayer, Yas Maghdouri-White, Anna A. Bulysheva, and Michael P. Francis

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Consistent and Reproducible Cultures of Large-Scale 3D Mammary Epithelial Structures Using an Accessible Bioprinting Platform, John A. Reid, Peter M. Mollica, Robert D. Bruno, and Patrick C. Sachs

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IL-12 Gene Electrotransfer Triggers a Change in Immune Response Within Mouse Tumors, Guilan Shi, Chelsea Edelblute, Sezgi Arpag, Cathryn Lundberg, and Richard Heller

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Upregulation of DNA Sensors in B16.F10 Melanoma Spheroid Cells After Electrotransfer of pDNA, Katarina Znidar, Masa Bosnjak, Tanja Jesenko, Loree C. Heller, and Maja Cemazar

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Tumor Cell Death After Electrotransfer of Plasmid DNA is Associated With Cytosolic DNA Sensor Upregulation, Katarina Znidar, Masa Bosnjak, Nina Semenova, Olga N. Pakhomova, Loree Heller, and Maja Cemazar

Submissions from 2017

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Mammary Extracellular Matrix Directs Differentiation of Testicular and Embryonic Stem Cells to Form Functional Mammary Glands In Vivo, Robert D. Bruno, Jodie M. Fleming, Andrea L. George, Corinne A. Boulanger, Pepper Schedin, and Gilbert H. Smith

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Electrotransfer of Plasmid DNA Radiosensitizes B16F10 Tumors Through Activation of Immune Response, Richard Heller

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Anaplasma Phagocytophilum Infection Modulates Expression of Megakaryocyte Cell Cycle Genes Through Phosphatidylinositol-3-Kinase Signaling, Supreet Khanal, Hameeda Sultana, John D. Catravas, Jason A. Carlyon, and Girish Neelakanta

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A Neighborhood-Wide Association Study (NWAS): Example of Prostate Cancer Aggressiveness, Shannon M. Lynch, Nandita Mitra, Michelle Ross, Craig Newcomb, Karl Dailey, Tara Jackson, Charnita M. Zeigler-Johnson, and Harold Riethman

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High-Throughput Single-Molecule Telomere Characterization, Jennifer McCaffrey, Eleanor Young, Katy Lassahn, Justin Sibert, Steven Pastor, Harold Riethman, and Ming Xiao

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Activation of the Phospholipid Scramblase TMEM16F by Nanosecond Pulsed Electric Field (nsPEF) Facilitates Its Diverse Cytophysiological Effects, Claudia Muratori, Andrei G. Pakhomov, Elena Gianulis, Jade Meads, Maura Casciola, Peter A. Mollica, and Olga N. Pakhomova

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Preferential Lineage-Specific Differentiation of Osteoblast-Derived Induced Pluripotent Stem Cells into Osteoprogenitors, Casey L. Roberts, Silvia S. Chen, Angela C. Murchison, Rebecca A. Ogle, Michael P. Francis, Roy C. Ogle, and Patrick C. Sachs

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Tissue Specific Microenvironments: A Key Tool for Tissue Engineering and Regenerative Medicine, Patrick C. Sachs, Peter A. Mollica, and Robert D. Bruno

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Ebola virus - Epidemiology, Diagnosis, and Control: Threat to Humans, Lessons Learnt, and Preparedness Plans - an Update on Its 40 Year's Journey, Raj Kumar Singh, Kuldeep Dhama, Yashpal Singh Malik, Muthannan Andavar Ramakrishnan, Kumaragurubaran Karthik, Rekha Khandia, Ruchi Tiwari, Ashok Munjal, Mani Saminathan, Perumal Arumugam, and Sunil Kumar Joshi

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Neurotrophic Factors NGF, GDNF and NTN Selectively Modulate HSV1 and HSV2 Lytic Infection and Reactivation in Primary Adult Sensory and Autonomic Neurons, Andy Y. Yanez, Telvin Harrell, Heather J. Sriranganathan, Angela M. Ives, and Andrea S. Bertke

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High-Throughput Single-Molecule Mapping Links Subtelomeric Variants and Long-Range Haplotypes with Specific Telomeres, Eleanor Young, Steven Pastor, Ramakrishnan Rajagopalan, Jennifer McCaffrey, Justin Sibert, Angel C. Y. Mak, Pui-Yan Kwok, Harold Riethman, and Ming Xiao

Submissions from 2016

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Vascular Endothelial Growth Factor-A Gene Electrotransfer Promotes Angiogenesis in a Porcine Model of Cardiac Ischemia, Anna A. Bulysheva, Barbara Hargrave, Nina Burcus, Cathryn G. Lundberg, Len Murray, and Richard Heller

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Modeling Early Stage Bone Regeneration With Biomimetic Electrospun Fibrinogen Nanofibers and Adipose-Derived Mesenchymal Stem Cells, Michael P. Francis, Yas M. Moghaddam-White, Patrick C. Sachs, Matthew J. Beckman, Stephen M. Chen, Gary L. Bowlin, Lynne W. Elmore, and Shawn E. Holt

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Nanosecond Pulsed Platelet-Rich Plasma (nsPRP) Improves Mechanical and Electrial Cardiac Function Following Myocardial Reperfusion Injury, Barbara Y. Hargrave, Frency Varghese, Nektarios Barabutis, John Catravas, and Christian Zemlin

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Race, Ethnicity, Psychosocial Factors, and Telomere Length in a Multicenter Setting, Shannon M. Lynch, M. K. Peek, Nandita Mitra, Krithika Ravichandran, Charles Branas, Elaine Spangler, Wenting Zhou, Electra D. Paskett, Sarah Gehlert, Cecilia DeGraffinreid, Timothy R. Rebbeck, and Harold Riethman

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Accessible Bioprinting: Adaptation of a Low-Cost 3D-Printer for Precise Cell Placement and Stem Cell Differentiation, John A. Reid, Peter A. Mollica, Garett D. Johnson, Roy C. Ogle, Robert D. Bruno, and Patrick C. Sachs

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Enhanced Osseous Integration of Human Trabecular Allografts Following Surface Modification With Bioactive Lipids, Tiffany Wang, Jack Krieger, Cynthia Huang, Anusuya Das, Michael P. Francis, Roy Ogle, and Edward Botchwey

Submissions from 2015

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Designing a Broad-Spectrum Integrative Approach for Cancer Prevention and Treatment, Keith I. Block, Charlotte Gyllenhaal, Leroy Lowe, Amedeo Amedei, A.R.M. Ruhul Amin, Amr Amin, Katia Aquilano, Jack Arbiser, Alexandra Arreola, Alla Arzumanyan, and Patricia Hentosh

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Bioactive Lipid Coating of Bone Allografts Direct Engraftment and Fate Determination of Bone Marrow-Derived Cells in Rat GFP Chimeras, Anusuya Das, Claire E. Segar, Yihsuan Chu, Tiffany W. Wang, Yon Lin, Chunxi Yang, and Roy C. Ogle

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Donor Platelet Plasma Components Inactivate Sensitive and Multidrug Resistant Acinetobacter Baumannii Isolates, Chelsea M. Edelblute, Olga N. Pakhomova, Fanying Li, Barbara Y. Hargrave, and Loree C. Heller

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A Novel Cardiac Muscle-Derived Biomaterial Reduces Dyskinesia and Postinfarct Left Ventricular Remodeling in a Mouse Model of Myocardial Infarction, Daniel M. O'Connor, Nivedita K. Naresh, Bryan A. Piras, Yaqin Xu, Robert S. Smith, and Roy C. Ogle

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Therapeutic Targeting of Replicative Immortality, Paul Yaswen, Karen L. MacKenzie, W. Nicol Keith, Patricia Hentosh, Francis Rodier, Jiyue Zhu, Gary L. Firestone, Ander Matheu, Amancio Carnero, and Alan Bilsland

Submissions from 2014

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Paracrine-Rescued Lobulogenesis in Chimeric Outgrowths Comprising Progesterone-Receptor-Null Mammary Epithelium and Redirected Wild-Type Testicular Cells, Robert D. Bruno, Corinne A. Boulanger, Sonia M. Rosenfield, Lisa H. Anderson, John P. Lydon, and Gilbert H. Smith

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A Potential Mechanism For Extracellular Matrix Induction of Breast Cancer Cell Normality, Robert D. Bruno and Gilbert H. Smith

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A Potential Mechanism for Extracellular Matrix Induction of Breast Cancer Cell Normality, Robert D. Bruno and Gilbert H. Smith

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Leptin Regulates CD16 Expression on Human Monocytes in a Sex-Specific Manner, Joseph G. Cannon, Gyanendra Sharma, Gloria Sloan, Christiana Dimitropoulou, R. Randall Baker, Andrew Mazzoli, Barbara Kraj, Anthony Mulloy, and Miriam Cortez-Cooper

Submissions from 2013

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Embryonic Stem Cells Are Redirected to Non-Tumorigenic Epithelial Cell Fate by Interaction with the Mammary Microenvironment, Corinne A. Boulanger, Robert D. Bruno, David L. Mack, Monica Gonzales, Nadia P. Castro, David S. Salomon, and Gilbert H. Smith

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Late Developing Mammary Tumors and Hyperplasia Induced by a Low-Oncogenic Variant of Mouse Mammary Tumor Virus (MMTV) Express Genes Identical to Those Induced by Canonical MMTV, Robert D. Bruno

Submissions from 2012

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Alignment and Composition of Laminin-Polycaprolactone Nanofiber Blends Enhance Peripheral Nerve Regeneration, Rebekah A. Neal, Sunil S. Tholpady, Patricia L. Foley, Nathan Swami, Roy C. Ogle, and Edward A. Botchwey

Submissions from 2011

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Follicle-Stimulating Hormone Promotes RANK Expression on Human Monocytes, Joseph G. Cannon, Barbara Kraj, and Gloria Sloan

Submissions from 2005

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Improving Clinical Practice Using Clinical Decision Support Systems: A Systematic Review of Trials to Identify Features Critical to Success, Kensaku Kawamoto, Caitlin A. Houlihan, E. Andrew Balas, and David F. Lobach

Submissions from 2004

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How Many Slides? Documented Cytotechnologist Workload, Sophie K, Thompson and Eileen Mason

Submissions from 2000

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Applications of Wavelet Transforms in Biomedical Optoacoustics, Zibiao Wei, Shujun Yang, Amin N. Dharamsi, and Barbara Hargrave

Submissions from 1999

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Insulinlike Growth Factor 1- and 2-Augmented Collagen Gel Repair of Facial Osseous Defects, James S. Toung, Roy C. Ogle, Raymond F. Morgan, and William H. Lindsey

Submissions from 1995

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Molecular Cloning and Rare Cleavage Mapping of Human 2P, 6Q, 8Q, 12Q, and 18Q Telomeres, Roberto A. Macina, Ken Morii, Xue-Lan Hu, Dimitri G. Negorev, Chrysanthe Spais, Lisa A. Ruthig, and Harold C. Riethman

Submissions from 1990

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Laminin Potentiates Differentiation of PCC4uva Embryonal Carcinoma into Neurons, T. M. Sweeney, Roy C. Ogle, and C. D. Little

Submissions from 1989

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Collagen Binding Proteins Derived from the Embryonic Fibroblast Cell Surface Recognize Arginine-Glycine-Aspartic Acid, Roy C. Ogle and Charles D. Little

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Embryonic Chicken Fibroblast Collagen Binding Proteins: Distribution, Role in Substratum Adhesion, and Relationship to Integrins, Roy C. Ogle, A. Jeannette Potts, Marchall Yacoe, and Charles D. Little

Submissions from 1988

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The Characterization of Ribosomal RNA Gene Chromatin from Physarum Polycephalum, Sally A. Amero, Vicky L. Montoya, Wendy L. Murdoch, Roy C. Ogle, John L. Keating, and Robert M. Grainger

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The Purification of Ribosomal RNA Gene Chromatin from Physarum Polycephalum, Sally A. Amero, Roy C. Ogle, John L. Keating, Vicky L. Montoya, Wendy L. Murdoch, and Robert M. Grainger

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Laminin Receptors for Neurite Formation, H. K. Kleinman, Roy C. Ogle, F. B. Cannon, C. D. Little, T. M. Sweeney, and L. Luckenbill-Edds