Targeting the Dysregulation of Peroxiporins for Cancer Therapy
Document Type
Abstract
Publication Date
11-7-2024
DOI
10.25776/wzgj-wb76
Abstract
Peroxiporins are a subgroup of aquaporins (AQPs) that enable the selective passage of hydrogen peroxide (H2O2) and other reactive oxygen species (ROS) across biological membranes. Peroxiporins play critical roles in redox homeostasis, cell signaling, oxidative stress, immune function, and metabolic regulation. The dysregulation of peroxiporins is associated with cancer, chronic inflammation, neurodegenerative and cardiovascular disorders. Clinical data shows that redox imbalance and peroxiporin dysregulation are associated with multiple cancer types and impact on patients’ survival. Several strategies targeting peroxiporin-redox imbalance were proposed and investigated. Pancreatic cancer appears more sensitive to exogenous H2O2 and cold atmospheric plasma (CAP). Importantly, nanosecond electric pulse (nsEP) treatment can upregulate multiple peroxiporins and further sensitize pancreatic cancer cells to CAP treatment. Our discoveries suggest peroxiporins are potential targets for pancreatic cancer. Further studies are warranted to determine the role of peroxiporins in the synergistic effect of CAP and nsEP treatment and validate these discoveries in preclinical animal tumor models.
Repository Citation
Guo, Siqi, "Targeting the Dysregulation of Peroxiporins for Cancer Therapy" (2024). 2024 Frank Reidy Research Center for Bioelectrics Retreat. 2.
https://digitalcommons.odu.edu/bioelectrics-2024retreat/2
