Document Type
Article
Publication Date
5-2000
Publication Title
Gene Therapy
Volume
7
Issue
10
Pages
826-829
DOI
10.1038/sj.gt.3301173
Abstract
Gene therapy by direct delivery of plasmid DNA has several advantages over viral gene transfer, but plasmid delivery is less efficient. In vivo electroporation has been used to enhance delivery of chemotherapeutic agents to tumors in both animal and human studies. Recently, this delivery technique has been extended to large molecules such as plasmid DNA. Here, the successful delivery of plasmids encoding reporter genes to rat hepatocellular carcinomas by in vivo electroporation is demonstrated.
Original Publication Citation
Heller, L., Jaroszeski, M. J., Coppola, D., Pottinger, C., Gilbert, R., & Heller, R. (2000). Electrically mediated plasmid DNA delivery to hepatocellular carcinomas in vivo. Gene Therapy, 7(10), 826-829. doi:10.1038/sj.gt.3301173
Repository Citation
Heller, L.; Jaroszeski, M. J.; Coppola, D.; Pottinger, C.; Gilbert, R.; and Heller, Richard, "Electrically Mediated Plasmid DNA Delivery to Hepatocellular Carcinomas in Vivo" (2000). Bioelectrics Publications. 103.
https://digitalcommons.odu.edu/bioelectrics_pubs/103
ORCID
0000-0001-8084-0787 (Heller, L.), 0000-0003-1899-3859 (Heller, R.)
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Biochemistry Commons, Biotechnology Commons, Genetics Commons, Molecular Biology Commons, Oncology Commons