Document Type
Article
Publication Date
2002
Publication Title
Physical Review E
Volume
65
Issue
4
Pages
041920
DOI
10.1103/PhysRevE.65.041920
Abstract
A self-consistent model analysis of electroporation in biological cells has been carried out based on an improved energy model. The simple energy model used in the literature is somewhat incorrect and unphysical for a variety of reasons. Our model for the pore formation energy E(r) includes a dependence on pore population and density. It also allows for variable surface tension, incorporates the effects of finite conductivity on the electrostatic correction term, and is dynamic in nature. Self-consistent calculations, based on a coupled scheme involving the Smoluchowski equation and the improved energy model, are presented. It is shown that E(r) becomes self-adjusting with variations in its magnitude and profile, in response to pore population, and inhibits uncontrolled pore growth and expansion. This theory can be augmented to include pore-pore interactions to move beyond the independent pore picture.
Original Publication Citation
Joshi, R. P., Hu, Q., Schoenbach, K. H., & Hjalmarson, H. P. (2002). Improved energy model for membrane electroporation in biological cells subjected to electrical pulses. Physical Review E, 65(4), 041920. doi:10.1103/PhysRevE.65.041920
Repository Citation
Joshi, R. P.; Hu, Q.; Schoenbach, K. H.; and Hjalmarson, H. P., "Improved Energy Model for Membrane Electroporation in Biological Cells Subjected to Electrical Pulses" (2002). Bioelectrics Publications. 241.
https://digitalcommons.odu.edu/bioelectrics_pubs/241
ORCID
0000-0001-7867-7773 (Schoenbach)
Included in
Cell Biology Commons, Electrical and Electronics Commons, Medicine and Health Sciences Commons
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